Invention Grant
US08541033B2 Production of human antibodies using NOD/SCID/γcnull mice
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使用NOD / SCID / gammacnull小鼠生产人抗体
- Patent Title: Production of human antibodies using NOD/SCID/γcnull mice
- Patent Title (中): 使用NOD / SCID / gammacnull小鼠生产人抗体
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Application No.: US12620469Application Date: 2009-11-17
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Publication No.: US08541033B2Publication Date: 2013-09-24
- Inventor: Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
- Applicant: Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
- Applicant Address: JP Kanagawa
- Assignee: Central Institute for Experimental Animals
- Current Assignee: Central Institute for Experimental Animals
- Current Assignee Address: JP Kanagawa
- Agency: Arnold & Porter LLP
- Agent Ginger R. Dreger; Victoria L. Boyd
- Priority: JP2000-367296 20001201
- Main IPC: A61K35/28
- IPC: A61K35/28 ; C12P21/00 ; A01K67/00
Abstract:
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
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