A method and device for pass-by breakpoint setting and debugging. The pass-by breakpoint setting method comprises: receiving a breakpoint setting command; determining an instruction at a breakpoint in a source program code according to the breakpoint setting command; if one of the instruction at the breakpoint and an instruction prior to the instruction at the breakpoint is a relative jump instruction, setting an instruction duplicate, and setting the instruction at the breakpoint in the source program code as a first abnormal instruction.