Invention Grant
US08697672B2 Microrna inhibition for the treatment of inflammation and myeloproliferative disorders
有权
Microrna抑制治疗炎症和骨髓增生性疾病
- Patent Title: Microrna inhibition for the treatment of inflammation and myeloproliferative disorders
- Patent Title (中): Microrna抑制治疗炎症和骨髓增生性疾病
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Application No.: US12122595Application Date: 2008-05-16
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Publication No.: US08697672B2Publication Date: 2014-04-15
- Inventor: David Baltimore , Ryan O'Connell , Konstantin Taganov , Mark Boldin
- Applicant: David Baltimore , Ryan O'Connell , Konstantin Taganov , Mark Boldin
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Knobbe, Martens, Olson & Bear LLP
- Main IPC: A01N43/04
- IPC: A01N43/04 ; C12Q1/68
Abstract:
The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing and treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1α, Sla, Cepbβ, and Bach1, and the like.
Public/Granted literature
- US20080300211A1 MICRORNA INHIBITION FOR THE TREATMENT OF INFLAMMATION AND MYELOPROLIFERATIVE DISORDERS Public/Granted day:2008-12-04
Information query
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