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    Regulation of macrophage activation using miR-125b
    3.
    发明授权
    Regulation of macrophage activation using miR-125b 有权
    使用miR-125b调节巨噬细胞活化

    公开(公告)号：US08685727B2

    公开(公告)日：2014-04-01

    申请号：US13526347

    申请日：2012-06-18

    Applicant: Aadel Chaudhuri ,  Alex Steven So ,  David Baltimore ,  Ryan M. O'Connell

    Inventor： Aadel Chaudhuri ,  Alex Steven So ,  David Baltimore ,  Ryan M. O'Connell

    IPC: C12N15/85 ,  C07H21/02 ,  C07H21/04

    CPC classification number: A61K31/7088

    Abstract: The present disclosure relates to regulation of macrophage activation by delivering of miRNAs, for example miR-125b or anti-miR-125b, to macrophages. For example, in some embodiments, macrophage activation can be elevated or reduced by administering miR-125b or anti-miR-125b oligonucleotides. Also disclosed are methods for promoting T cell activation and method for treating various disorders such as tumor and autoimmune diseases.

    Abstract translation: 本公开涉及通过向巨噬细胞递送miRNA（例如miR-125b或抗miR-125b）来调节巨噬细胞活化。 例如，在一些实施方案中，可通过施用miR-125b或抗miR-125b寡核苷酸来升高或降低巨噬细胞活化。 还公开了促进T细胞活化的方法和用于治疗各种疾病如肿瘤和自身免疫性疾病的方法。

    Use of SAM68 for modulating signaling through the TNF receptor
    4.
    发明授权
    Use of SAM68 for modulating signaling through the TNF receptor 有权
    使用SAM68通过TNF受体调节信号

    公开(公告)号：US08598137B2

    公开(公告)日：2013-12-03

    申请号：US13284792

    申请日：2011-10-28

    Applicant: Parameswaran Ramakrishnan ,  David Baltimore

    Inventor： Parameswaran Ramakrishnan ,  David Baltimore

    IPC: C12N15/113 ,  A61K39/395 ,  C07H21/04

    CPC classification number: A61K31/7105 ,  C12N15/1135 ,  C12N2310/14

    Abstract: Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent signaling, for example to inhibit NF-kB signaling or apoptosis in a patient in need. In some embodiments, functional Sam68 is administered to increase TNF-dependent signaling, for example to induce apoptosis in a patient in need. In some embodiments, methods are provided determining whether the TNF-dependent or TNF-independent branch of a signaling pathway is active in a cell or cells, or for drug screening applications.

    Abstract translation: Sam68在TNF依赖性信号传导中起重要作用，包括NF-kB信号传导和凋亡的外在激活。 在一些实施方案中，施用Sam68的抑制剂以抑制TNF依赖性信号传导，例如抑制需要的患者中的NF-kB信号传导或凋亡。 在一些实施方案中，施用功能性Sam68以增加TNF依赖性信号传导，例如在需要的患者中诱导细胞凋亡。 在一些实施方案中，提供了确定信号传导途径的TNF依赖性或不依赖于TNF的分支在细胞或细胞中活性或用于药物筛选应用的方法。

    Isolation of unknown rearranged T-cell receptors from single cells
    5.
    发明授权
    Isolation of unknown rearranged T-cell receptors from single cells 有权
    从单细胞中分离未知重排的T细胞受体

    公开(公告)号：US08497071B2

    公开(公告)日：2013-07-30

    申请号：US12824744

    申请日：2010-06-28

    Applicant: Alejandro Benjamin Balazs ,  Jonathan Michael Tsai ,  David Baltimore

    Inventor： Alejandro Benjamin Balazs ,  Jonathan Michael Tsai ,  David Baltimore

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C07K14/705 ,  C07K14/3156

    Abstract: Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome amplification (WGA). A series of PCR reactions is carried out to enrich the genomic template for sequences encoding the TCR alpha and beta chains, and then to isolate the sequences encoding the TCR alpha and beta chains.

    Abstract translation: 本文公开了用于从单细胞分离和鉴定T细胞受体的方法和材料。 在一些实施方案中，使用全基因组扩增（WGA）分离来自单个T细胞的基因组DNA。 进行一系列PCR反应以丰富编码TCRα和β链的序列的基因组模板，然后分离编码TCRα和β链的序列。

    MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146
    7.
    发明申请
    MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 审中-公开
    通过MICRORNA MIR-146调节免疫系统发育和功能

    公开(公告)号：US20110258716A1

    公开(公告)日：2011-10-20

    申请号：US13151053

    申请日：2011-06-01

    Applicant: David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    Inventor： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    IPC: A01K67/027 ,  C12N5/10

    CPC classification number: C12N15/113 ,  C12N2310/111 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2330/10

    Abstract: The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.

    Abstract translation: 本公开涉及微RNA-146在调节免疫系统的发育和功能中起作用的发现。 免疫细胞发育和功能可以通过将microRNA-146（miR-146）或反义miR-146递送到靶向免疫细胞或前体细胞来调节。 例如，在一些实施方案中，通过施用miR-146寡核苷酸或抗miR-146寡核苷酸调节某些免疫细胞的活性和/或增殖。 在其它实施方案中，通过施用miR-146寡核苷酸或抗miR-146调节免疫细胞中的促炎细胞因子表达。 在另外的实施方案中，提供了使用反义miR-146调节巨噬细胞活性的方法。 公开了使用miR-146调节免疫系统功能和发育的其它方法和组合物。

    METHOD OF TARGETED GENE DELIVERY USING VIRAL VECTORS
    8.
    发明申请
    METHOD OF TARGETED GENE DELIVERY USING VIRAL VECTORS 有权
    使用病毒载体的目标基因传递方法

    公开(公告)号：US20110212530A1

    公开(公告)日：2011-09-01

    申请号：US13041115

    申请日：2011-03-04

    Applicant: David Baltimore ,  Pin Wang ,  Lili Yang

    Inventor： David Baltimore ,  Pin Wang ,  Lili Yang

    IPC: C12N15/63

    CPC classification number: C12N15/86 ,  A61K2039/505 ,  C07K16/2887 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/03 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2799/027 ,  C12N2810/80 ,  C12N2810/851 ,  C12N2810/859 ,  Y02A50/386 ,  Y02A50/396

    Abstract: Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.

    Abstract translation: 提供了使用病毒将编码目标基因的多核苷酸递送至靶细胞的方法和组合物。 病毒包膜包含识别和结合靶细胞表面上的组分的细胞特异性结合决定簇，导致病毒的内吞。 单独的融合分子也存在于包膜上并促进多核苷酸穿过膜并进入靶细胞的胞质溶胶。 方法和相关组合物可用于治疗患有广泛病症（包括HIV感染）的患者; 癌症，如非霍奇金淋巴瘤和乳腺癌; 和血液学疾病，如严重的联合免疫缺陷。

    ISOLATION OF UNKNOWN REARRANGED T-CELL RECEPTORS FROM SINGLE CELLS
    10.
    发明申请
    ISOLATION OF UNKNOWN REARRANGED T-CELL RECEPTORS FROM SINGLE CELLS 有权
    从单细胞中分离未知的已知的T细胞受体

    公开(公告)号：US20110014659A1

    公开(公告)日：2011-01-20

    申请号：US12824744

    申请日：2010-06-28

    Applicant: Alejandro Benjamin Balazs ,  Jonathan Michael Tsai ,  David Baltimore

    Inventor： Alejandro Benjamin Balazs ,  Jonathan Michael Tsai ,  David Baltimore

    IPC: C12P19/34 ,  C07H21/04

    CPC classification number: C07K14/705 ,  C07K14/3156

    Abstract: Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome amplification (WGA). A series of PCR reactions is carried out to enrich the genomic template for sequences encoding the TCR alpha and beta chains, and then to isolate the sequences encoding the TCR alpha and beta chains.

    Abstract translation: 本文公开了用于从单细胞分离和鉴定T细胞受体的方法和材料。 在一些实施方案中，使用全基因组扩增（WGA）分离来自单个T细胞的基因组DNA。 进行一系列PCR反应以丰富编码TCRα和β链的序列的基因组模板，然后分离编码TCRα和β链的序列。

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