A method for two-stage packet aggregation facing wireless sensor network with hybrid topology structure including: building various nodes in a wireless sensor network into a hybrid topology structure which combines the star topology and mesh topology; establishing a two-stage packet aggregation architecture for periodic sensor data based on the above described topology structure; determining the packet format, aggregating and disaggregating the two-stage packets based on the topology structure and aggregation architecture; according to the application, the aggregated nodes in the network configuring router nodes and aggregation attributes of the nodes; according to the aggregation attribute, the sensor nodes performing the first-stage aggregation and generates an first-stage aggregation packet; according to the aggregation attributes, the router node implementing second-stage aggregation and generating a second-stage aggregation packet; the aggregation nodes taking charge of disaggregating the aggregated packets. Embodiments of the invention adopt the above described hybrid topology structure, feature a two-stage packet aggregation method, decrease the overhead of packet-head, reduce the energy consumption of the nodes and inter-node interference, and save communication resources.