Time-to-digital converters adapted to analog and digital inputs and methods of use are described. A time-to-digital converter has an event frame latches and logic module with memory cells, an analog front-end module connected to the memory cells, and a bin increment generator module connected to the memory cells. The bin increment generator is configured to issue bin increments separated by a time increment, and the analog front end is configured to issue a start event followed by a plurality of stop events. Upon receipt of a first time increment following a start event, the event frame latches and logic module updates a first memory cell with a first bit-type; upon receipt of a second time increment following an intervening stop event, the event frame latches and logic module updates a second memory cell with a second bit-type different from the first bit-type.