Apparatus and methods for image processing using multiple imaging devices are provided. A first imaging device is configured to acquire a first image of a portion of a printed substrate and the second imaging device is configured to acquire a second image of a portion of the printed substrate. At least a portion of the first image and the second image are acquired from the same portion of the printed substrate at the same time. The first imaging device is configured to process color data from the first image using a first processing circuit of the first imaging device and the second imaging device is configured to process spatial information from the second image using a separate second processing circuit of the second imaging device.