An integrated circuit with multiple clock domain tracing capability includes a debug module including a global time stamp counter for counting pulses of a reference clock signal to provide a global time stamp, a first granularity counter for counting pulses of a first clock signal to provide a first granularity count, a second granularity counter for counting pulses of a second clock signal to provide a second granularity count and a trace cache buffer for selectively storing in a first partition the global time stamp, the first granularity count, and first data synchronous to the first clock signal, and for selectively storing in a second partition the global time stamp, the second granularity count, and second data synchronous to the second clock signal.