Invention Grant
US08927295B2 Method and apparatus for conversion of multiple analyte cation types to a single analyte anion type via ion/ion charge inversion
有权
通过离子/离子电荷反转将多种分析物阳离子类型转化成单一分析物阴离子型的方法和装置
- Patent Title: Method and apparatus for conversion of multiple analyte cation types to a single analyte anion type via ion/ion charge inversion
- Patent Title (中): 通过离子/离子电荷反转将多种分析物阳离子类型转化成单一分析物阴离子型的方法和装置
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Application No.: US12874819Application Date: 2010-09-02
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Publication No.: US08927295B2Publication Date: 2015-01-06
- Inventor: Kerry M. Hassell , Scott A. McLuckey , Yves Leblanc
- Applicant: Kerry M. Hassell , Scott A. McLuckey , Yves Leblanc
- Applicant Address: US IN West Lafayette
- Assignee: Purdue Research Foundation
- Current Assignee: Purdue Research Foundation
- Current Assignee Address: US IN West Lafayette
- Agency: Brinks Gilson & Lione
- Main IPC: G01N24/00
- IPC: G01N24/00 ; H01J49/00
Abstract:
An apparatus and method for a sample using a mass spectrometer is described, including, generating ions of a first polarity from an analyte using electrospray ionization; generating ions of a second polarity from a reagent; injecting the ions of the first polarity and ions of the second polarity in sequence into a chamber of the mass spectrometer such that the ions of the first polarity and the ions of the second polarity interact in the chamber to form analyte ions having the second polarity; and, analyzing the mass spectrum of the analyte ions of the second polarity. A reagent such as a polyamidomine is selected to preferentially yield analyte ions of the second polarity having a desired mass-to-charge ratio.
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