Invention Grant
US08932629B2 Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations 有权
共加工微晶纤维素和糖醇作为片剂制剂的赋形剂

Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations
Abstract:
A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.
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