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    Coating composition
    1.
    发明申请
    Coating composition 审中-公开
    涂料组成

    公开(公告)号：US20060127451A1

    公开(公告)日：2006-06-15

    申请号：US11232690

    申请日：2005-09-22

    Applicant: Michael Augello ,  Sharon Ray ,  Jian-Xin Li ,  Brian Carlin

    Inventor： Michael Augello ,  Sharon Ray ,  Jian-Xin Li ,  Brian Carlin

    IPC: A61K9/68 ,  A61K9/20 ,  A61K31/717

    CPC classification number: A61K9/2886 ,  A61K9/2826 ,  A61K9/2853 ,  A61K9/286 ,  A61K9/2866 ,  A61K9/7007 ,  A61K31/717

    Abstract: The present invention is directed to compositions containing: (i) sugar and/or a sugar substitute and (ii) microcrystalline cellulose present in an amount equal to greater than 41% of the total weight of the composition. The present invention is also directed to compositions containing: (i) sugar and/or a sugar substitute and (ii) microcrystalline cellulose having an average particle size equal to or less than 20 microns and present in an amount equal to or greater than 20% of the total weight of the composition. The compositions of the present invention are useful in coating a wide variety of solid forms such as pharmaceutical dosage forms, veterinary dosage forms, nutraceutical dosage forms, food, industrial material, cosmetic material or oral care material. The compositions of the invention are also useful as films such as cast films. The present invention is also directed to methods of making such compositions, as well as methods of coating such compositions on solid forms.

    Abstract translation: 本发明涉及含有：（i）糖和/或糖替代物的组合物和（ii）等于大于组合物总重量的41％量的微晶纤维素。 本发明还涉及含有：（i）糖和/或糖替代物的组合物和（ii）平均粒度等于或小于20微米并且以等于或大于20％的量存在的微晶纤维素， 的组合物的总重量。 本发明的组合物可用于涂覆各种固体形式，例如药物剂型，兽用剂型，营养制剂剂型，食品，工业材料，化妆品材料或口腔护理材料。 本发明的组合物也可用作薄膜如流延膜。 本发明还涉及制备这种组合物的方法，以及在固体形式上涂覆这些组合物的方法。

    Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations
    4.
    发明授权
    Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations 有权
    共加工微晶纤维素和糖醇作为片剂制剂的赋形剂

    公开(公告)号：US08932629B2

    公开(公告)日：2015-01-13

    申请号：US11925235

    申请日：2007-10-26

    Applicant: Jian-Xin Li ,  Brian Carlin ,  Thomas Ruszkay

    Inventor： Jian-Xin Li ,  Brian Carlin ,  Thomas Ruszkay

    IPC: A61K9/20 ,  B27N3/00 ,  A61K9/16

    CPC classification number: A61K9/1623 ,  A61K9/1652 ,  A61K9/1682 ,  A61K9/2018 ,  A61K9/2054

    Abstract: A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.

    Abstract translation: 公开了一种包含微晶纤维素和至少一种糖醇的颗粒状共处理组合物。 优选的糖醇是甘露糖醇。 在制备固体剂量制剂如片剂时，与微晶纤维素和至少一种糖醇单独或组合地作为简单的干混合物相比，该组合物具有改进的紧实性，润滑剂敏感性和喷射曲线。 还公开了包含颗粒状共处理组合物，活性物质和任选的一种或多种其它赋形剂的片剂及其制备方法。

    COATING PROCESS TO PRODUCE CONTROLLED RELEASE COATINGS
    5.
    发明申请
    COATING PROCESS TO PRODUCE CONTROLLED RELEASE COATINGS 失效
    涂装工艺生产控释材料

    公开(公告)号：US20070184198A1

    公开(公告)日：2007-08-09

    申请号：US11669748

    申请日：2007-01-31

    Applicant: JIAN-XIN LI ,  BRIAN A.C. CARLIN

    Inventor： JIAN-XIN LI ,  BRIAN A.C. CARLIN

    IPC: B05D3/02 ,  B05D7/00

    CPC classification number: B05D3/0486 ,  A61K9/2813 ,  A61K9/282 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/2893 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5089 ,  B01J2/006 ,  B01J2/30 ,  B05D3/0254 ,  B05D2401/20

    Abstract: An aqueous polymer coating composition containing at least one latex or pseudolatex is coated on a substrate in a high humidity coating process followed by heat treatment of the coated substrate above the film forming temperature of the coating at low humidity. The coated substrate gives a stable reproducible dissolution profile substantially insensitive to temperature or humidity conditions upon storage. The high humidity coating process is achieved by addition of water to the coating chamber through dilution of the coating formulation or humidification of inlet air. Contrary to the conventional low humidity coating process, residual water is retained in the coating layer of the coated substrates in the coating step. When the coated substrates are heat treated at a temperature greater than the minimum film forming temperature, the residual water in the coating layer will ensure adequate capillary force for the completion of film coalescence. High humidity heat treatment is not needed.

    Abstract translation: 含有至少一种乳胶或假胶体的含水聚合物涂料组合物在高湿度涂布过程中涂覆在基材上，随后将涂覆的基材在低湿度下在涂层的成膜温度之上进行热处理。 涂覆的基材在储存时提供基本上对温度或湿度条件不敏感的稳定的可再现溶出曲线。 高湿度涂覆方法是通过将涂料配方稀释或加入入口空气向涂布室中加入水来实现的。 与传统的低湿度涂覆方法相反，在涂布步骤中残留的水保留在涂覆的基材的涂层中。 当涂覆的基材在大于最低成膜温度的温度下进行热处理时，涂层中的残留水将确保用于完成膜聚结的足够的毛细作用力。 不需要高湿度热处理。

    Coating process to produce controlled release coatings
    7.
    发明授权
    Coating process to produce controlled release coatings 失效
    涂层工艺生产控释层

    公开(公告)号：US07829148B2

    公开(公告)日：2010-11-09

    申请号：US11669748

    申请日：2007-01-31

    Applicant: Jian-Xin Li ,  Brian A. C. Carlin

    Inventor： Jian-Xin Li ,  Brian A. C. Carlin

    IPC: B05D3/02

    CPC classification number: B05D3/0486 ,  A61K9/2813 ,  A61K9/282 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/2893 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5089 ,  B01J2/006 ,  B01J2/30 ,  B05D3/0254 ,  B05D2401/20

    Abstract: An aqueous polymer coating composition containing at least one latex or pseudolatex is coated on a substrate in a high humidity coating process followed by heat treatment of the coated substrate above the film forming temperature of the coating at low humidity. The coated substrate gives a stable reproducible dissolution profile substantially insensitive to temperature or humidity conditions upon storage. The high humidity coating process is achieved by addition of water to the coating chamber through dilution of the coating formulation or humidification of inlet air. Contrary to the conventional low humidity coating process, residual water is retained in the coating layer of the coated substrates in the coating step. When the coated substrates are heat treated at a temperature greater than the minimum film forming temperature, the residual water in the coating layer will ensure adequate capillary force for the completion of film coalescence. High humidity heat treatment is not needed.

    Abstract translation: 含有至少一种乳胶或假胶体的含水聚合物涂料组合物在高湿度涂覆过程中涂覆在基材上，随后将涂覆的基材在低湿度下在涂层的成膜温度之上进行热处理。 涂覆的基材在储存时提供基本上对温度或湿度条件不敏感的稳定的可再现溶出曲线。 高湿度涂覆方法是通过稀释涂料配方或加入入口空气将水添加到涂层室来实现的。 与传统的低湿度涂覆方法相反，在涂布步骤中残留的水保留在涂覆的基材的涂层中。 当涂覆的基材在大于最低成膜温度的温度下进行热处理时，涂层中的残留水将确保用于完成膜聚结的足够的毛细作用力。 不需要高湿度热处理。

    SYRINGE PLUNGER
    8.
    发明申请
    SYRINGE PLUNGER 审中-公开

    公开(公告)号：US20100030159A1

    公开(公告)日：2010-02-04

    申请号：US12524978

    申请日：2007-11-19

    Applicant: Jian-Xin Li

    Inventor： Jian-Xin Li

    IPC: A61M5/315 ,  B29C45/14

    CPC classification number: B29C45/14 ,  A61M5/31511

    Abstract: A syringe plunger has a hole is arranged in its plunger central axis, with a diaphragm arranged in the hole. The thickness of the diaphragm in the hole is from 0.01 mm to 0.5 mm. A manufacturing method of a syringe plunger includes the steps of: adding pigment into medical rubber and stirring uniformly; each of a fixed die and a movable die of a medical rubber syringe die being embedded with an impacting and penetrating needle, when molding and die closing, space between the impacting and penetrating needles of the fixed die and the movable die being 0.01 mm to 0.5 mm; demolding said molded medical rubber plunger.

    Abstract translation: 注射器柱塞在其柱塞中心轴线上设置有孔，隔膜布置在孔中。 孔中的隔膜的厚度为0.01mm〜0.5mm。 注射器柱塞的制造方法包括以下步骤：将颜料加入到医用橡胶中并均匀搅拌; 每个固定模具和医用橡胶注射器模具的可移动模具都嵌有冲击穿刺针，当模制和模具闭合时，固定模具和可动模具的冲击和穿透针之间的空间为0.01mm至0.5 毫米 所述模制医用橡胶柱塞脱模。

    CO-PROCESSED MICROCRYSTALLINE CELLULOSE AND SUGAR ALCOHOL AS AN EXCIPIENT FOR TABLET FORMULATIONS
    9.
    发明申请
    CO-PROCESSED MICROCRYSTALLINE CELLULOSE AND SUGAR ALCOHOL AS AN EXCIPIENT FOR TABLET FORMULATIONS 有权
    CO处理的微晶纤维素和糖醇作为片剂配方的特殊物质

    公开(公告)号：US20080131505A1

    公开(公告)日：2008-06-05

    申请号：US11925235

    申请日：2007-10-26

    Applicant: Jian-Xin Li ,  Brian Carlin ,  Thomas Ruszkay

    Inventor： Jian-Xin Li ,  Brian Carlin ,  Thomas Ruszkay

    IPC: A61K9/20 ,  B27N3/00

    CPC classification number: A61K9/1623 ,  A61K9/1652 ,  A61K9/1682 ,  A61K9/2018 ,  A61K9/2054

    Abstract: A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.

    Abstract translation: 公开了一种包含微晶纤维素和至少一种糖醇的颗粒状共处理组合物。 优选的糖醇是甘露糖醇。 在制备固体剂量制剂如片剂时，与微晶纤维素和至少一种糖醇单独或组合地作为简单的干混合物相比，该组合物具有改进的紧实性，润滑剂敏感性和喷射曲线。 还公开了包含颗粒状共处理组合物，活性物质和任选的一种或多种其它赋形剂的片剂及其制备方法。

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