A method is performed in a requester device that is coupled with a responder device by a serial interface. The method is one of selecting an approach to handle an error in a request-response communication between the requester and responder devices over the serial interface. The method includes transmitting a request packet, of the request-response communication, over the serial interface, based on a request from an application that is executing on a logical processor. The method includes reporting the error in the request-response communication to an application-layer module. The method includes selecting an error handling approach, of a plurality of error handling approaches, which is to be used to handle the error, with the application-layer module.