Invention Grant
US09249231B2 Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif
有权
与特异性结合切割的半胱天冬酶基序的母体特异性和上下文相关抗体
- Patent Title: Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif
- Patent Title (中): 与特异性结合切割的半胱天冬酶基序的母体特异性和上下文相关抗体
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Application No.: US13289651Application Date: 2011-11-04
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Publication No.: US09249231B2Publication Date: 2016-02-02
- Inventor: Michael Comb , Ailan Guo , John Edward Rush, II , Jun-Ming Cai , Jing Li , Jing Zhou
- Applicant: Michael Comb , Ailan Guo , John Edward Rush, II , Jun-Ming Cai , Jing Li , Jing Zhou
- Applicant Address: US MA Danvers
- Assignee: Cell Signaling Technology, Inc.
- Current Assignee: Cell Signaling Technology, Inc.
- Current Assignee Address: US MA Danvers
- Main IPC: C07K16/44
- IPC: C07K16/44 ; C07K16/00 ; C12N5/07
Abstract:
There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.
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