An interactive operation method of an electronic apparatus is provided. An image sequence is captured by an image capturing unit. An image pre-processing is executed on an image of the image sequence. A fingertip candidate region is obtained from the image. Whether the fingertip candidate region is connected with a hand region is determined. If the fingertip candidate region is connected with the hand region, the fingertip candidate region serves as a target fingertip region. Whether a click event occurs is determined by continuously tracking the target fingertip region. When the click event occurs, a corresponding function is executed.