Invention Grant
US09279806B2 Water-soluble AIE luminogens for monitoring and retardation of fibrillation of amyloid proteins
有权
用于监测和延缓淀粉样蛋白原纤维的水溶性AIE发光剂
- Patent Title: Water-soluble AIE luminogens for monitoring and retardation of fibrillation of amyloid proteins
- Patent Title (中): 用于监测和延缓淀粉样蛋白原纤维的水溶性AIE发光剂
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Application No.: US14171957Application Date: 2014-02-04
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Publication No.: US09279806B2Publication Date: 2016-03-08
- Inventor: Benzhong Tang , Yuning Hong , Sijie Chen , Tsz Kin Ryan Kwok , Wai Tung Leung
- Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
- Applicant Address: CN Clear Water Bay Kowloon, Hong Kong
- Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
- Current Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: CN Clear Water Bay Kowloon, Hong Kong
- Agency: Nath, Goldberg & Meyer
- Agent Joshua Goldberg
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; G01N33/53 ; G01N33/543 ; G01N33/542 ; G01N21/64 ; G01N21/77

Abstract:
Compounds that exhibit aggregation induced emission (AIE), and more particularly to water-soluble conjugated polyene compounds that exhibit aggregation induced emission. The conjugated polyene compounds can be used as bioprobes for DNA detection, G-quadruplex identification, and potassium-ion sensing. The polyenes also can be utilized as an external fluorescent marker to study conformational structures, to monitor folding processes of label-free oligonucleotides with G-rich strand sequences, and to visualize DNA bands in PAGE assay. The polyenes have applications in high-throughput anticancer drug screening and are useful for the development of efficient anti-cancer drugs. Furthermore, the present subject matter can also be used to monitor fibrillation of amyloid proteins and to facilitate the storage and delivery thereof.
Public/Granted literature
- US20150031607A1 WATER-SOLUBLE AIE LUMINOGENS FOR MONITORING AND RETARDATION OF FIBRILLATION OF AMYLOID PROTEINS Public/Granted day:2015-01-29
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