An entity interaction recognition system algorithmically recognizes a variety of different types of entity interactions that may be captured in two-dimensional images. In some embodiments, the system estimates the three-dimensional spatial configuration or arrangement of entities depicted in the image. In some embodiments, the system applies a proxemics-based analysis to determine an interaction type. In some embodiments, the system infers, from a characteristic of an entity detected in an image, an area or entity of interest in the image.