There is disclosed a honeycomb structure usable as a support of a honeycomb catalyst onto which a large amount of catalyst can be loaded and which has a good purification efficiency, and the honeycomb structure includes porous partition walls 5 defining a plurality of cells to form through channels of a fluid and having a plurality of pores 10 therein, wherein a porosity of the partition walls 5 is from 45 to 70%, and in a cross section perpendicular to an extending direction of the cells, a total area of macro pores 12 having the largest pore diameter of larger than 10 μm is 50% or more with respect to a total area of the pores 10.