Invention Grant
- Patent Title: Methods of treatment using modulators of SIRT2
- Patent Title (中): 使用SIRT2调节剂治疗的方法
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Application No.: US14349140Application Date: 2012-10-05
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Publication No.: US09359293B2Publication Date: 2016-06-07
- Inventor: Hening Lin , Bin He
- Applicant: CORNELL UNIVERSITY
- Applicant Address: US NY Ithaca
- Assignee: CORNELL UNIVERSITY
- Current Assignee: CORNELL UNIVERSITY
- Current Assignee Address: US NY Ithaca
- Agency: Scully, Scott, Murphy & Presser, P.C.
- International Application: PCT/US2012/058846 WO 20121005
- International Announcement: WO2013/052727 WO 20130411
- Main IPC: C07C327/42
- IPC: C07C327/42 ; A61K31/16
Abstract:
The instant application describes novel compounds that modulate (in particular, inhibit) Sirt2 , with structures according to Formulas (1) and (2) provided herein. The invention is also directed to pharmaceutical compositions thereof, methods of treatment (i.e., cancer and neurodegenerative disease) by administration of the modulating compounds, assay methods for finding modulators of Sirt2 , and kits for practicing the assay method.
Public/Granted literature
- US20140249216A1 METHODS OF TREATMENT USING MODULATORS OF SIRT2 Public/Granted day:2014-09-04
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