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    POLY(CYCLIC VINYL ETHERS), COMPOSITIONS OF SAME, METHODS OF MAKING SAME AND USES THEREOF
    3.
    发明申请
    POLY(CYCLIC VINYL ETHERS), COMPOSITIONS OF SAME, METHODS OF MAKING SAME AND USES THEREOF 有权

    公开(公告)号：US20250145749A1

    公开(公告)日：2025-05-08

    申请号：US18685186

    申请日：2022-08-19

    Applicant: Cornell University

    Inventor： Brett P. FORS ,  Scott SPRING ,  Tristan H. LAMBERT ,  Veronika KOTTISCH

    IPC: C08F234/02 ,  C08F2/06

    Abstract: Poly(cyclic vinyl ethers) (PCVEs), compositions of same, methods of making same, and uses of same. In various examples, PCVEs (e.g., homopolymers and/or copolymers) comprise repeat units comprising cyclic vinyl ether (CVE) groups in the backbone (e.g., poly(2,3-dihydrofuran) and/or poly(3,4-dihydropyran)). In various examples, PCVE homopolymers comprise molecular weights (Mn and/or Mw) of 200 kilodalton (kD) or greater. In various examples, PCVE copolymers (e.g., random or block) comprise one or more CVE group(s) and/or additional (e.g., acyclic vinyl ether (AVE) and/or styrenic) group(s)). A method of preparing PCVEs comprises polymerizing monomers comprising CVE groups (e.g., 2,3-dihydrofuran and/or 3,4-dihydropyran). In various examples, pentakis(carbonylcyclopentadienes) (PCCPs) and/or hydrogen bond donors are polymerization catalysts and/or initiators. various examples, PCVEs are biorenewable, recyclable, thermoplastic materials that exhibit desirable optical clarity, desirable barrier properties to, e.g., oxygen, carbon dioxide, and water, and find uses in food packaging, windows, and the like.

    APT1 and APT2 Inhibitors and Uses Thereof
    7.
    发明申请
    APT1 and APT2 Inhibitors and Uses Thereof 有权

    公开(公告)号：US20250092067A1

    公开(公告)日：2025-03-20

    申请号：US18562243

    申请日：2022-05-19

    Applicant: Cornell University

    Inventor： Hening Lin ,  Kevin Wielenberg ,  Min Yang

    IPC: C07F5/02 ,  A61K31/496 ,  A61K31/675 ,  A61K31/69 ,  C07D409/06 ,  C07D495/04 ,  C07F9/6509 ,  C07F9/6558

    Abstract: Compounds, compositions including one or more of the compound(s), and methods of using the compounds and the compositions. The compounds comprise an (I) group. In various examples, a compound is an Acyl Protein Thioesterase 1 inhibitor (APT1 inhibitor) and/or an Acyl Protein Thioesterase 2 inhibitor (APT2 inhibitor). Compound(s) or composition(s), which may be pharmaceutical composition(s), can be used in methods of treating diseases or disorders, such as, for example, autoimmune disorders, neurodegenerative disorders, inflammatory disorders, and immune-mediated cancer diseases.

    DECENTRALIZED TECHNIQUES FOR VERIFICATION OF DATA IN TRANSPORT LAYER SECURITY AND OTHER CONTEXTS
    9.
    发明申请
    DECENTRALIZED TECHNIQUES FOR VERIFICATION OF DATA IN TRANSPORT LAYER SECURITY AND OTHER CONTEXTS 有权

    公开(公告)号：US20250088516A1

    公开(公告)日：2025-03-13

    申请号：US18897934

    申请日：2024-09-26

    Applicant: Cornell University

    Inventor： Fan Zhang ,  Sai Krishna Deepak Maram ,  Harjasleen Malvai ,  Steven Goldfeder ,  Ari Juels

    IPC: H04L9/40

    Abstract: A verifier device in one embodiment is configured to communicate over one or more networks with a client device and a server device. The verifier device participates in a three-party handshake protocol with the client device and the server device in which the verifier device and the client device obtain respective shares of a session key of a secure session with the server device. The verifier device receives from the client device a commitment relating to the secure session with the server device, and responsive to receipt of the commitment, releases to the client device additional information relating to the secure session that was not previously accessible to the client device. The verifier device verifies correctness of at least one characterization of data obtained by the client device from the server device as part of the secure session, based at least in part on the commitment and the additional information.

    COMPOSITIONS AND METHODS FOR SOLUBILIZING GLYCOSYLTRANSFERASES
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR SOLUBILIZING GLYCOSYLTRANSFERASES 有权

    公开(公告)号：US20250066746A1

    公开(公告)日：2025-02-27

    申请号：US18725018

    申请日：2023-01-06

    Applicant: CORNELL UNIVERSITY

    Inventor： Matthew DELISA ,  Thapakorn JAROENTOMEECHAI ,  Dario MIZRACHI

    IPC: C12N9/10 ,  C07K14/775 ,  C07K16/00 ,  C12N15/62

    Abstract: The present disclosure relates to a nucleic acid construct having a chimeric nucleic acid molecule encoding a tripartite glycosyltransferase fusion protein. The chimeric nucleic acid molecule includes a first nucleic acid moiety encoding an amphipathic shield domain protein; a second nucleic acid moiety encoding a glycosyltransferase; and a third nucleic acid moiety encoding a water soluble expression decoy protein. The first nucleic acid moiety is coupled to the second nucleic acid moiety's 3′ end and the third nucleic acid moiety is coupled to the second nucleic acid moiety's 5′ end. The coupling may be direct or indirect. The present disclosure further relates to an expression vector, a host cell, and a tripartite glycosyltransferase fusion protein encoded by the nucleic acid construct. Also disclosed are methods of recombinantly producing a tripartite glycosyltransferase fusion protein in soluble form and methods of cell-free glycan remodeling.

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