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US09359396B2 Material for supported synthesis and method for growing oligonucleotides or peptides 有权
用于支持合成的材料和用于生长寡核苷酸或肽的方法

Material for supported synthesis and method for growing oligonucleotides or peptides
Abstract:
The invention concerns a material composed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support, and in that the support is silica-based and is in the form of porous particles of heterogeneous shape and size, the size of the particles being larger than 1 μm and preferably within the range of 5 to 200 μm.The invention further concerns a growth method for oligonucleotides or peptides characterized in that growth is performed on a material formed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least a part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support.
Abstract(Chinese):

本发明涉及一种由多孔载体组成的材料，功能化纳米颗粒通过共价键接枝在其上，其特征在于通过共价键接枝的至少部分纳米颗粒被容纳在载体的表面孔内，并且载体是二氧化硅 - 并且呈不均匀形状和尺寸的多孔颗粒的形式，颗粒的尺寸大于1μm，优选在5至200μm的范围内。 本发明还涉及一种用于寡核苷酸或肽的生长方法，其特征在于在由多孔载体形成的材料上进行生长，多孔载体上通过共价键接枝官能化纳米颗粒，其特征在于，通过共价键接枝的至少一部分纳米颗粒是 容纳在支撑体的内表面孔中。

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