A method and system to help manage wireless communication with a UE in a manner that takes into account a predicted impact of data bundling, such as TTI bundling, with respect to communication of data during a session. When a radio access network (RAN) is going to serve a UE with data communication for a VoLTE call or other session that would trigger such bundling, the RAN will predict the extent of other data that will be communicated during the session, and the RAN will predict the impact, such as increased air interface load, that would result from data bundling of at least that other data communication. If the RAN thereby predicts that the impact of data bundling with respect to at least that other data communication will exceed a predefined threshold level, then the RAN will responsively take action to limit its air interface communication with the UE.