Invention Grant
US09540617B2 Method for producing horseradish peroxidase recombinant protein using filamentous fungus
有权
使用丝状真菌生产辣根过氧化物酶重组蛋白的方法
- Patent Title: Method for producing horseradish peroxidase recombinant protein using filamentous fungus
- Patent Title (中): 使用丝状真菌生产辣根过氧化物酶重组蛋白的方法
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Application No.: US14404076Application Date: 2013-05-30
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Publication No.: US09540617B2Publication Date: 2017-01-10
- Inventor: Fumikazu Yokoyama , Kaoru Okakura , Atsushi Inoue , Koichiro Murashima , Toshiaki Nagasato , Koji Yanai , Akitaka Nakane
- Applicant: MEIJI SEIKA PHARMA CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: MEIJI SEIKA PHARMA CO., LTD.
- Current Assignee: MEIJI SEIKA PHARMA CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JP2012-124598 20120531
- International Application: PCT/JP2013/064995 WO 20130530
- International Announcement: WO2013/180208 WO 20131205
- Main IPC: C12Q1/28
- IPC: C12Q1/28 ; G01N33/535 ; D06L3/11 ; G01N33/58 ; C12N9/08
Abstract:
A modified polynucleotide has a different base sequence in at least one codon from a wild-type base sequence encoding a horseradish peroxidase polypeptide. The usage frequency of the modified codon of the polynucleotide corresponds to the codon usage frequencies of three filamentous fungal species in Humicola, Aspergillus, and Trichoderma. The polynucleotide is capable of expressing the polypeptide to be encoded in a filamentous fungus.
Public/Granted literature
- US20150140574A1 METHOD FOR PRODUCING HORSERADISH PEROXIDASE RECOMBINANT PROTEIN USING FILAMENTOUS FUNGUS Public/Granted day:2015-05-21
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