公开(公告)号：US12168794B2

公开(公告)日：2024-12-17

申请号：US17281063

申请日：2019-10-02

Applicant: OSLER DIAGNOSTICS LIMITED

Inventor： Stanislav Sokolov ,  James Merotra ,  Konstantinos Psarros ,  Samuel Whitby ,  Adriano Dos Santos ,  Flavio Cesar Bedatty Fernandes

IPC: G01N27/327 ,  C12Q1/00 ,  C12Q1/28

Abstract: Disclosed herein is a method for detecting a binding event between an immobilised primary antibody and a target analyte-secondary antibody-enzyme complex using an electrochemical measurement technique.

公开(公告)号：US12158430B2

公开(公告)日：2024-12-03

申请号：US17205460

申请日：2021-03-18

Applicant: Johnson & Johnson Consumer Inc.

Inventor： Curt Binner ,  Justin Mellinger ,  Alexandru Paunescu

IPC: G01N21/78 ,  A61F13/42 ,  A61F13/49 ,  B01L3/00 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N21/31 ,  G01N33/493 ,  G01N33/52 ,  G01N21/77

Abstract: A disposable indicator component for use in a system for measuring analyte concentration in a bodily fluid includes an indicator zone comprising at least one colorimetric analyte sensing element, and a coupler for coupling the indicator component to a component having at least one spectrophotometer contained within a housing.

公开(公告)号：US20240093265A1

公开(公告)日：2024-03-21

申请号：US17942555

申请日：2022-09-12

Applicant: Concert Pharmaceuticals, Inc.

Inventor： Roger Tung

IPC: C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/00 ,  C07D221/28 ,  C07D471/08 ,  G01N33/49 ,  G01N33/493

CPC classification number: C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/002 ,  C07D221/28 ,  C07D471/08 ,  G01N33/491 ,  G01N33/493

Abstract: This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.

公开(公告)号：US20230384309A1

公开(公告)日：2023-11-30

申请号：US18026442

申请日：2020-09-15

Applicant: The Brigham and Women's Hospital, Inc.

Inventor： Mohamed Shehata DRAZ ,  Hadi SHAFIEE

IPC: G01N33/569 ,  C12Q1/28 ,  B01L3/00 ,  G06T7/00 ,  G16H10/40 ,  G16H40/67 ,  G16H50/20

CPC classification number: G01N33/56983 ,  C12Q1/28 ,  B01L3/502761 ,  G06T7/0014 ,  G16H10/40 ,  G16H40/67 ,  G16H50/20 ,  B01L2200/0652 ,  B01L2200/16 ,  G01N2333/908 ,  G01N2469/10 ,  B01L2300/027 ,  G06T2207/20084 ,  G06T2207/30004 ,  G06T2207/20076

Abstract: A system for virus detection in a sample from a subject includes a microchip comprising at least one channel containing the sample from the subject and a mobile device. The sample is processed with nanoparticles and a catalyzer that are configured to generate gas bubbles in the presence of a target virus on a surface of the microchip. The mobile device includes a camera configured to acquire an image of the microchip containing the sample from the subject, a neural network configured to receive the acquired image and to generate a probability regarding the presence of the target virus in the sample from the subject based on the acquired image, and a display coupled to the neural network and configured to display the probability regarding presence of the target virus in the sample from the subject.

公开(公告)号：US20230304066A1

公开(公告)日：2023-09-28

申请号：US18020883

申请日：2021-09-07

Applicant: Baebies, Inc.

Inventor： Michael A. BASMAJIAN ,  Jennifer ELDERBROOM ,  Maithri KRISHNAMURTHY ,  Erik BURDE ,  Michael BOSO ,  Daniel Hull ,  Rainer NG ,  Vijay SRINIVASAN ,  Ramakrishna SISTA ,  Vamsee PAMULA

IPC: C12Q1/28 ,  B01L3/00

CPC classification number: C12Q1/28 ,  B01L3/502715 ,  B01L2200/16 ,  B01L2400/0427 ,  B01L2200/04 ,  G01N2333/908 ,  G01N2800/085

Abstract: A method for assaying analytes in a blood sample by loading a blood sample onto a microfluidic device; combining the blood sample with a buffer reagent comprising a surfactant to provide a diluted blood sample and conduct an assay. The surfactant is selected to permit the use of electrowetting to conduct droplet operations using the blood sample and to permit the use of a fluorescence-based droplet operation. The assay may be an unbound bilirubin assay.

公开(公告)号：US20230159978A1

公开(公告)日：2023-05-25

申请号：US17930462

申请日：2022-09-08

Applicant: ExxonMobil Technology and Engineering Company

Inventor： Xiaozhou Zhang ,  Mohor Chatterjee

IPC: C12Q1/28 ,  C12P7/04 ,  C12P7/24 ,  C12P3/00 ,  C12N9/04 ,  C12N9/88

CPC classification number: C12Q1/28 ,  C12P7/04 ,  C12P7/24 ,  C12P3/00 ,  C12N9/0006 ,  C12Y101/0302 ,  C12N9/88 ,  C12Y402/01053

Abstract: A variety of methods and systems for screening biocatalysts are disclosed, including, in one embodiment, a screening method for identifying engineered biocatalysts, including reacting an olefin with water in the presence of an engineered biocatalyst to produce at least a fatty alcohol having from 4 carbons to 24 carbons; reacting at least a portion of the fatty alcohol with oxygen in the present of a fatty alcohol oxidase to produce a fatty aldehyde and hydrogen peroxide, the fatty aldehyde having from 4 carbons to 24 carbons; and measuring activity of the engineered biocatalyst.

公开(公告)号：US11573183B2

公开(公告)日：2023-02-07

申请号：US17156027

申请日：2021-01-22

Applicant: CYANAGEN S.r.l.

Inventor： Leopoldo Della Ciana ,  Lorenzo Biagini ,  Thomas Paul Jansen ,  Rossana Perciaccante ,  Manuela Vargiolu ,  Marina Eleonora Vettraino

IPC: G01N21/76 ,  C12Q1/28 ,  G01N21/78 ,  G01N33/573 ,  G01N33/58

Abstract: A kit for performing an assay for determining an analyte in a sample with an extended shelf-life, wherein the kit comprises a chemiluminescent cyclic dihydrazide, an enhancer, a co-enhancer, and a peroxide oxidizer. The kit is useful in blot assays and immunoassays for the detection of proteins and nucleic acid molecules.

公开(公告)号：US11513109B2

公开(公告)日：2022-11-29

申请号：US16016606

申请日：2018-06-24

Applicant: NANJING UNIVERSITY

Inventor： Jinju Geng ,  Yingying Fu ,  Xingsheng Gao ,  Hongqiang Ren

IPC: G01N33/18 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/30

Abstract: A biological toxicity test method for evaluating an ecological safety of an advanced oxidation process comprising the following steps: (1) collecting (preparing) a waste water to be determined; (2) collecting the waste water and a tap water after the advanced oxidation process treatment; (3) subjecting Koi (Cyprinus carpio haematopterus) to the water after treatment for exposure to poison; (4) Determining an anti-oxidation enzyme activity of a liver of the Koi after exposure; (5) Data analyzing. By comparing the changes of liver enzyme activities in different water, the present method evaluates the toxicity changes of micro-pollutant containing water before and after treatment, which fills in the gap of the ecological risk assessment for advanced oxidation technology.

公开(公告)号：US20220354908A1

公开(公告)日：2022-11-10

申请号：US17579006

申请日：2022-01-19

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Heli Putaala ,  Sofia Forssten ,  Sampo Lahtinen ,  Arthur Ouwehand ,  Jaana Mättö ,  Harri Mäkivuokko ,  Inger Mattsby-Baltzer ,  Björn Andersch

IPC: A61K35/747 ,  A61P31/00 ,  C12Q1/28 ,  C12N1/20 ,  A61K35/745

Abstract: The present invention relates to bacteria and metabolites thereof that are capable of binding to vaginal cells and producing hydrogen peroxide, their use in probiotic compositions and food products and methods for their selection. The invention also relates to the use of said bacteria, metabolites and probiotic compositions for the prevention and/or treatment of urogenital disorders.

公开(公告)号：US20220348980A1

公开(公告)日：2022-11-03

申请号：US17733531

申请日：2022-04-29

Applicant: KYOTO LUMINOUS SCIENCE LABORATORY

Inventor： Hajime KARATANI

IPC: C12Q1/28

Abstract: A further high-sensitive method for detection, determination, and activity measurement of peroxidase with no special enhancer argent. The substance, for example, high-concentration ammonium sulfate, is dissolved in the reaction solution to give rise to the micro-hydrophobic property, for detection, determination, and activity measurement of peroxidase using luminol and hydrogen peroxide as substrates.