Invention Grant
US09550992B2 Compositions and methods for modulating myeloid derived suppressor cells
有权
调节骨髓来源的抑制细胞的组合物和方法
- Patent Title: Compositions and methods for modulating myeloid derived suppressor cells
- Patent Title (中): 调节骨髓来源的抑制细胞的组合物和方法
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Application No.: US14361537Application Date: 2012-12-03
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Publication No.: US09550992B2Publication Date: 2017-01-24
- Inventor: Shyam S. Mohapatra , Srinivas Nagaraj Bharadwaj , Subhra Mohapatra
- Applicant: UNIVERSITY OF SOUTH FLORIDA , Shyam S. Mohapatra , Srinivas Nagaraj Bharadwaj , Subhra Mohapatra
- Applicant Address: US FL Tampa
- Assignee: University of South Florida
- Current Assignee: University of South Florida
- Current Assignee Address: US FL Tampa
- Agency: Thomas | Horstemeyer, LLP
- International Application: PCT/US2012/067586 WO 20121203
- International Announcement: WO2013/082591 WO 20130606
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113 ; C12Q1/68 ; C12N5/0789 ; C12N5/0784 ; C12N5/0786
Abstract:
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (MDSC). In particular, described herein are miR-142 polynucleotides and miR-223 polynucleotides that can be used to modulate differentiation of MDSCs. Increased differentiation of a MDSC population, or cells within an MDSC population, can be achieved by increasing the miR-142 and/or miR-223 polynucleotides in a MDSC.
Public/Granted literature
- US20140336239A1 COMPOSITIONS AND METHODS FOR MODULATING MYELOID DERIVED SUPPRESSOR CELLS Public/Granted day:2014-11-13
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