Invention Grant
US09579327B2 Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones
有权
手性2-（1H-吲唑-6-基） - 螺[环丙烷-1,3'-二氢吲哚] -2'-酮的合成
![Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones](/docs/US/2017-02-28/US09579327B2/abs.jpg.600x600.jpg)
- Patent Title: Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones
- Patent Title (中): 手性2-（1H-吲唑-6-基） - 螺[环丙烷-1,3'-二氢吲哚] -2'-酮的合成
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Application No.: US14580658Application Date: 2014-12-23
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Publication No.: US09579327B2Publication Date: 2017-02-28
- Inventor: Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
- Applicant: University Health Network
- Applicant Address: CA Toronto
- Assignee: University Health Network
- Current Assignee: University Health Network
- Current Assignee Address: CA Toronto
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Wei Song
- Priority: WOPCT/CA2010/000518 20100406
- Main IPC: C07D403/04
- IPC: C07D403/04 ; C07D231/56 ; A61K31/5377 ; C07D413/14 ; C07D403/10 ; C07D403/14 ; A61K45/06
![Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones](/abs-image/US/2017/02/28/US09579327B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
Public/Granted literature
- US20150133677A1 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES Public/Granted day:2015-05-14
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