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![SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES](/abs-image/US/2015/05/14/US20150133677A1/abs.jpg.150x150.jpg)
1.发明申请SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES 有权合成2-（1H-吲哚-6-YL） - 吡啶[环丙基-1,3'-吲哚] -2'-ONES公开(公告)号：US20150133677A1
公开(公告)日：2015-05-14
申请号：US14580658
申请日：2014-12-23
Applicant: University Health Network
Inventor： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
IPC: C07D403/04 , C07D231/56
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
Abstract translation: 本发明涉及用于制备由结构式（A）表示的螺环丙基吲哚啉酮化合物或其药学上可接受的盐的新型合成方法。 还包括本文所述的合成中间体。
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Patent Agency Ranking
![Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones](/abs-image/US/2017/02/28/US09579327B2/abs.jpg.150x150.jpg)
2.发明授权Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones 有权手性2-（1H-吲唑-6-基） - 螺[环丙烷-1,3'-二氢吲哚] -2'-酮的合成公开(公告)号：US09579327B2
公开(公告)日：2017-02-28
申请号：US14580658
申请日：2014-12-23
Applicant: University Health Network
Inventor： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
IPC: C07D403/04 , C07D231/56 , A61K31/5377 , C07D413/14 , C07D403/10 , C07D403/14 , A61K45/06
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
Abstract translation: 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：由该结构式表示的化合物是激酶抑制剂，因此本文公开了用于治疗癌症的化合物。 本文提供了结构式中变量的定义。
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![SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES](/abs-image/US/2018/04/19/US20180105511A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180105511A1
公开(公告)日：2018-04-19
申请号：US15790847
申请日：2017-10-23
Applicant: University Health Network
Inventor： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
IPC: C07D403/10 , C07D413/14 , C07D403/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
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![Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones](/abs-image/US/2017/10/24/US09796703B2/abs.jpg.150x150.jpg)
公开(公告)号：US09796703B2
公开(公告)日：2017-10-24
申请号：US15440548
申请日：2017-02-23
Applicant: University Health Network
Inventor： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
IPC: C07D403/10 , C07D403/14 , C07D413/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
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![Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones](/abs-image/US/2018/09/18/US10077255B2/abs.jpg.150x150.jpg)
公开(公告)号：US10077255B2
公开(公告)日：2018-09-18
申请号：US15790847
申请日：2017-10-23
Applicant: University Health Network
Inventor： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
IPC: C07D403/10 , C07D413/14 , C07D403/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
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![SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES](/abs-image/US/2017/08/10/US20170226088A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170226088A1
公开(公告)日：2017-08-10
申请号：US15440548
申请日：2017-02-23
Applicant: University Health Network
Inventor： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
IPC: C07D403/10 , C07D403/14 , C07D413/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
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