Techniques for transmitting data with transmit diversity for single-carrier frequency division multiple access (SC-FDMA) are described. In one design, a transmitter (e.g., a UE) may form a first symbol vector including first and second modulation symbol sequences. The transmitter may also form a second symbol vector including third and fourth modulation symbol sequences, which may be generated based on the second and first modulation symbol sequences, respectively. Each symbol vector may further include a cyclic prefix and possibly a cyclic postfix for each modulation symbol sequence. The transmitter may generate a first SC-FDMA symbol based on the first symbol vector and a second SC-FDMA symbol based on the second symbol vector. The transmitter may transmit the first and second SC-FDMA symbols from two transmit antennas in a single SC-FDMA symbol period to achieve transmit diversity.