Invention Grant
- Patent Title: Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs
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Application No.: US14467851Application Date: 2014-08-25
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Publication No.: US09611491B2Publication Date: 2017-04-04
- Inventor: David H. Sherman , Garth D. Ehrlich , Benjamin Janto , Robert M. Williams , Christopher M. Rath
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ALLEGHENY-SINGER RESEARCH INSTITUTE , COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
- Applicant Address: US MI Ann Arbor US PA Pittsburgh US CO Fort Collins
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,ALLEGHENY-SINGER RESEARCH INSTITUTE,COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,ALLEGHENY-SINGER RESEARCH INSTITUTE,COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
- Current Assignee Address: US MI Ann Arbor US PA Pittsburgh US CO Fort Collins
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: C12N9/88
- IPC: C12N9/88 ; C12N15/00 ; C12N1/20 ; C12P17/18 ; C07H21/04 ; C07K1/00 ; C12N15/52 ; C12N15/70
Abstract:
The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
Public/Granted literature
- US20150050704A1 BIOSYNTHETIC PATHWAY FOR HETEROLOGOUS EXPRESSION OF A NONRIBOSOMAL PEPTIDE SYNTHETASE DRUG AND ANALOGS Public/Granted day:2015-02-19
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