In a navigation system and method, location-aware adjustments may be made to the accuracy and/or power of the navigation system by changing at least one setting of a navigation system receiver in response to at least one characteristic of a navigation route and/or an estimated current position of the receiver. By providing location-aware adjustments, the accuracy may be increased when a higher accuracy is desired and may be decreased when a lower accuracy is sufficient based on the receiver location. A higher accuracy setting may be used, for example, when the estimated current position of a navigation system receiver is within the vicinity of a waypoint along the navigation route and a lower accuracy setting may be used at other times to reduce power consumption. Of course, many alternatives, variations, and modifications are possible without departing from this embodiment.