Invention Grant
- Patent Title: Modified biotin, mutant streptavidin, and use thereof
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Application No.: US14768916Application Date: 2014-02-18
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Publication No.: US09670255B2Publication Date: 2017-06-06
- Inventor: Akira Sugiyama , Hirofumi Doi , Tatsuhiko Kodama , Tsuyoshi Inoue , Eiichi Mizohata , Tatsuya Kawato , Tomohiro Meshizuka , Motomu Kanai , Yohei Shimizu , Tomohiro Yamamoto
- Applicant: SAVID THERAPEUTICS INC.
- Applicant Address: JP Tokyo
- Assignee: SAVID THERAPEUTICS INC.
- Current Assignee: SAVID THERAPEUTICS INC.
- Current Assignee Address: JP Tokyo
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP2013-031038 20130220
- International Application: PCT/JP2014/053734 WO 20140218
- International Announcement: WO2014/129446 WO 20140828
- Main IPC: C07K14/36
- IPC: C07K14/36 ; C07D495/04 ; C07D497/04 ; C07D498/04 ; G01N33/543
Abstract:
It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin having a high affinity for the mutant streptavidin with a reduced affinity for natural biotin. According to the present invention, there is provided a reagent kit for use in treatments or diagnoses, which comprises: (a) a mutant streptavidin with a reduced affinity for natural biotin or biocytin; and a modified biotin having a high affinity for the above-described mutant streptavidin.
Public/Granted literature
- US20160137704A1 MODIFIED BIOTIN, MUTANT STREPTAVIDIN, AND USE THEREOF Public/Granted day:2016-05-19
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