Embodiments of apparatus and methods for adaptively controlling air quality in a vehicle compartment are described. In embodiments, an apparatus may include a sensor interface configured to interface with one or more sensors, disposed at one or more locations at one or more sides or in an interior space of a vehicle compartment, and configured to measure one or more indicators of air quality at the one or more locations. The apparatus may further include one or more airflow controllers configured to adaptively control a plurality of ventilation components of the vehicle compartment to regulate airflow in the interior space, based at least in part on the measured indicators of air quality. Other embodiments may be described and/or claimed.