Invention Grant
- Patent Title: IL-9 secreting CD8+ Tc9 cells and methods of treating cancer
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Application No.: US14605112Application Date: 2015-01-26
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Publication No.: US09694033B2Publication Date: 2017-07-04
- Inventor: Qing Yi , Yong Lu
- Applicant: THE CLEVELAND CLINIC FOUNDATION
- Applicant Address: US OH Cleveland
- Assignee: The Cleveland Clinic Foundation
- Current Assignee: The Cleveland Clinic Foundation
- Current Assignee Address: US OH Cleveland
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- Main IPC: A61K35/00
- IPC: A61K35/00 ; A61K35/17 ; A61K31/675 ; C12N5/0783
Abstract:
A method of producing a population of CD8+ Tc9 lymphocytes is provided including priming a population of naïve CD8+ T cells by contacting the population of naïve CD8+ T cells with an immunogenic peptide, in the presence of a Tc9 supportive environment, thereby producing a population of CD8+ Tc9 lymphocytes which secrete IL-9. Purified populations of CD8+ Tc9 cells are also disclosed herein, as are method for their use in the treatment of cancer in a subject.
Public/Granted literature
- US20150209388A1 IL-9 SECRETING CD8+ Tc9 CELLS AND METHODS OF TREATING CANCER Public/Granted day:2015-07-30
Information query
