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    CONFIGURING A DEEP BRAIN STIMULATION (DBS) SYSTEM TO TREAT A NEUROLOGICAL DISORDER
    1.
    发明申请
    CONFIGURING A DEEP BRAIN STIMULATION (DBS) SYSTEM TO TREAT A NEUROLOGICAL DISORDER 有权

    公开(公告)号：US20250121190A1

    公开(公告)日：2025-04-17

    申请号：US18986810

    申请日：2024-12-19

    Applicant: THE CLEVELAND CLINIC FOUNDATION

    Inventor： Andre Machado ,  Raghavan Gopalakrishnan ,  Kenneth Baker

    IPC: A61N1/36 ,  A61N1/05

    Abstract: Deep brain stimulation (DBS) can be used to treat many neurological conditions beyond traditional movement disorders. When patients do not suffer from traditional movement disorders, medical professionals cannot use traditional observation-based methods to configure the DBS system. A new method for selecting stimulation configurations can include recording internal data and external data as the patient performs (or attempts to perform) a motor task. The internal data is electrophysiology data recorded by a plurality of DBS electrodes, used to identify at least one of the plurality of electrodes closest to a neuronal population involved in control of the at least one motor task. The external data is electroencephalogram (EEG) data recorded by scalp electrodes, which is used to select at least one of the potential stimulation electrodes to deliver the DBS. When the electrode(s) delivering the DBS are selected, optimal parameters for the DBS are then chosen.

    System and process for computerized screening and monitoring for cognitive characteristics
    2.
    发明授权
    System and process for computerized screening and monitoring for cognitive characteristics 有权

    公开(公告)号：US12257062B2

    公开(公告)日：2025-03-25

    申请号：US18084607

    申请日：2022-12-20

    Applicant: The Cleveland Clinic Foundation

    Inventor： Robyn M. Busch ,  Darlene P. Floden

    IPC: A61B5/00 ,  G16H10/20 ,  G16H10/60

    Abstract: A method and device includes generating and displaying a first set of objects and a second set of objects; displaying a first object belonging to either the first set of objects or the second set of objects; receiving a first response of whether the first object belongs to the first set of objects or the second set of objects; determining whether the first response correctly identifies a set of objects to which the first object belongs; displaying a second object from either the first set of objects or the second set of objects; receiving a second response of whether the first object belongs to the first set of objects or the second set of objects; determining whether the second response correctly identifies the set of objects to which the second object belongs; and applying an algorithm to determine a probability of a cognitive characteristic.

    APPARATUSES FOR AT LEAST PARTIALLY REPAIRING A REGURGITANT HEART VALVE
    3.
    发明申请
    APPARATUSES FOR AT LEAST PARTIALLY REPAIRING A REGURGITANT HEART VALVE 有权

    公开(公告)号：US20250090325A1

    公开(公告)日：2025-03-20

    申请号：US18729534

    申请日：2023-01-18

    Applicant: THE CLEVELAND CLINIC FOUNDATION

    Inventor： Jose Navia ,  Samir Kapadia ,  Torey Hovest

    IPC: A61F2/24

    Abstract: An apparatus for at least partially repairing a regurgitant heart valve includes at least one subvalvular device defining a longitudinal axis and including a subvalvular portion located adjacent a subvalvular cardiac wall adjacent to the heart valve. An anchor portion is adjacent to, and is longitudinally spaced from, the subvalvular portion. A connector neck is interposed longitudinally between, and is attached to both of, the subvalvular portion and the anchor portion. The connector neck penetrates longitudinally through at least one of a base of the first valve leaflet and an annulus of the heart valve at a manufactured puncture site. A fastener is selectively connected to the at least one subvalvular device. The fastener penetrates through at least one of the first and second valve leaflets to maintain the at least one leaflet in a predetermined position with respect to the at least one subvalvular device.

    DETECTING THE PRESENCE OF URINARY STONE DISEASE USING A PLURALITY OF URINARY METABOLITES
    5.
    发明申请
    DETECTING THE PRESENCE OF URINARY STONE DISEASE USING A PLURALITY OF URINARY METABOLITES 有权

    公开(公告)号：US20250076302A1

    公开(公告)日：2025-03-06

    申请号：US18740776

    申请日：2024-06-12

    Applicant: The Cleveland Clinic Foundation

    Inventor： Aaron W. Miller ,  Jose Agudelo

    IPC: G01N33/68 ,  G01N33/70 ,  G01N33/94

    Abstract: The present invention relates to systems, kits, and methods for identifying subjects with increased levels (e.g., in a urine sample) of at least two urine metabolites selected from: butanal; 2-Hydroxy-1,3-dimethoxy-8,9-methylenedioxycoumestan; 6-Methylmercaptopurine; Dimethyl-L-arginine; N-butanoyl-lhomoserine lactone; Hexanoylglycine; Methyl propenyl ketone; Ferulate; 2-Oxoarginine; and 2-Hydroxyestradiol-3-methyl ether, as well as methods of determining if a subject has or is at risk of urinary stone disease based on such urine metabolites. In certain embodiments, the urinary tract of a subject with elevated levels of at least two of the urine metabolites is imaged (e.g., to generate an image showing the size, location, or number of urinary stones present).

    MRNA VACCINE DESIGN VIA THE ALTERATION OF CODON USAGE
    8.
    发明申请
    MRNA VACCINE DESIGN VIA THE ALTERATION OF CODON USAGE 有权

    公开(公告)号：US20250000966A1

    公开(公告)日：2025-01-02

    申请号：US18701156

    申请日：2022-10-13

    Applicant: The Cleveland Clinic Foundation

    Inventor： Jae U. Jung ,  Chih-Jen Lai

    IPC: A61K39/215 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005

    Abstract: The present disclosure provides compositions and polynucleotides for increasing expression of an immunogenic and/or antigenic polypeptide (e.g., in a vaccine). The disclosure further provides methods of using the disclosed compositions, polynucleotides, and vaccines for the treatment of diseases and disorders (e.g., infections). The compositions and polynucleotides include a first nucleic acid encoding a viral regulatory protein and a second nucleic acid encoding an immunogenic polypeptide, wherein the immunogenic polypeptide is codon-optimized to a vims from which the regulatory protein is derived.

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