Invention Grant
- Patent Title: Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof
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Application No.: US13675685Application Date: 2012-11-13
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Publication No.: US09733185B2Publication Date: 2017-08-15
- Inventor: Han Cao , Jonas O. Tegenfeldt , Stephen Chou , Robert H. Austin
- Applicant: Princeton University
- Applicant Address: US NJ Princeton
- Assignee: Princeton University
- Current Assignee: Princeton University
- Current Assignee Address: US NJ Princeton
- Agency: Riverside Law LLP
- Main IPC: G01N35/02
- IPC: G01N35/02 ; G01N33/00 ; C12M1/36 ; C12M3/00 ; G01N21/64 ; B01L3/00 ; B81C1/00 ; B82Y30/00 ; G01N33/487 ; G03F7/20
Abstract:
The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.
Public/Granted literature
- US20140030811A1 Gradient Structures Interfacing Microfluidics and Nanofluidics, Methods for Fabrication and Uses Thereof Public/Granted day:2014-01-30
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