Invention Grant
- Patent Title: Method for preparing protein cage, and in situ method for preparing hydrophobic additive-supported core-shell structured polymer-protein particles
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Application No.: US14778906Application Date: 2013-10-11
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Publication No.: US09757342B2Publication Date: 2017-09-12
- Inventor: Hyun Jong Paik , Jae Kwang Song , Seong Soo An , Chae Yeon Lee , Jong Hwa Jeong , Mohammad Abdul Kadir , Tae Heon Lee
- Applicant: PUSAN NATIONAL UNIVERSITY INDUSTRY—UNIVERSITY COOPERATION FOUNDATION , KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , GACHON UNIVERSITY OF INDUSTRY—ACADEMIC COOPERATION FOUNDATION
- Applicant Address: KR Busan KR Daejeon KR Gyeonggi-do
- Assignee: Pusan National University Industry-University Cooperation Foundation,Korea Research Institute of Chemical Technology,Gachon University of Industry-Academic Cooperation Foundation
- Current Assignee: Pusan National University Industry-University Cooperation Foundation,Korea Research Institute of Chemical Technology,Gachon University of Industry-Academic Cooperation Foundation
- Current Assignee Address: KR Busan KR Daejeon KR Gyeonggi-do
- Agency: Norton Rose Fulbright US LLP
- Priority: KR10-2013-0031128 20130322
- International Application: PCT/KR2013/009120 WO 20131011
- International Announcement: WO2014/148713 WO 20140925
- Main IPC: A61K9/48
- IPC: A61K9/48 ; C08H1/00 ; A61K47/48 ; A61K8/64 ; A61Q19/00 ; A61K8/02 ; C08J3/24 ; A61K8/66 ; A61K49/00 ; C07K14/435 ; C07K14/75 ; A61K9/51 ; A61K39/00
Abstract:
The present invention relates to a method for preparing a protein cage which comprises: a 1st step of preparing an amphiphilic polymer comprising a 1st hydrophobic polymer and a 1st hydrophilic functional group; a 2nd step of preparing a hydrophilic protein comprising a 2nd functional group binding to the 1st functional group; a 3rd step of forming an amphiphilic polymer-protein hybrid by the binding of the 1st functional group and the 2nd functional group, and forming core-shell structured particles comprising a protein shell and an amphiphilic polymer core by the self-assembly of the amphiphilic polymer in a hydrophilic solvent; and a fourth step of removing some or all of the hydrophobic polymer of the core part from the core-shell structured particles.
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