An interrupt handling method and a system are provided. An exemplary embodiment of an interrupt handling method in a virtualized environment operable on a computer having one or more CPU cores, includes disabling a virtual machine exit triggers by an interrupt that destined to a virtual machine (VM), via a hypervisor of the virtualized environment. The exemplary method further includes delivering directly one or more interrupts from an I/O virtualization (IOV) device and a virtual device that destined to the VM, while the destined VM is running on one of the one or more CPU cores, otherwise delivering the one or more interrupts to the hypervisor to deliver corresponding one or more virtual interrupts to the destined VM.