Techniques are disclosed for synchronizing gain adjustments across a cascaded network of audio gain stages having variant operating delays. In particular, a delay-synchronized volume adjustment system configured in accordance with an embodiment of the present disclosure includes a controller operatively coupled to the cascaded network of audio and configured to apply gain adjustments in a synchronized manner that accounts for operating delays that are inherent to each gain stage. In an embodiment, the controller synchronously adjusts each gain stage relative to a corresponding operating delay such that gain adjustments fully propagate at substantially a same point in time within a given acceptable tolerance, and thus, eliminates or otherwise mitigates perceivable volume shifts when mixing audio from two or more audio sources.