Invention Grant
![Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones](/docs/US/2017-10-24/US09796703B2/abs.jpg.600x600.jpg)
- Patent Title: Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones
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Application No.: US15440548Application Date: 2017-02-23
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Publication No.: US09796703B2Publication Date: 2017-10-24
- Inventor: Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
- Applicant: University Health Network
- Applicant Address: CA Toronto
- Assignee: University Health Network
- Current Assignee: University Health Network
- Current Assignee Address: CA Toronto
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Wei Song
- Priority: WOPCT/CA2010/000518 20100406
- Main IPC: C07D403/10
- IPC: C07D403/10 ; C07D403/14 ; C07D413/14
![Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones](/abs-image/US/2017/10/24/US09796703B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
Public/Granted literature
- US20170226088A1 SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES Public/Granted day:2017-08-10
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