Techniques are disclosed relating to use of digital predistortion in the context of full-duplex radio. In some embodiments, an apparatus includes one or more antennas and is configured to simultaneously transmit and receive wireless signals via at least partially overlapping frequency resources using the one or more antennas. In some embodiments, the apparatus includes receive chain circuitry that is configured to process both wireless signals transmitted by the apparatus via the one or more antennas and over-the-air wireless signals from one or more other computing devices. In some embodiments, the apparatus includes one or more processing elements configured to determine one or more digital predistortion parameters based on the wireless signals transmitted by the apparatus via the one or more antennas and processed by the receive chain circuitry and apply predistortion to transmitted wireless signals based on the one or more digital predistortion parameters.