A pressurized garment has cuffs for encircling a human subject, each cuff having ports for cooling and grounding unit controlling the pressure and temperature of the coolant, where the pressurization and cooling may use common or separate cuff ports. The cuff has a coolant circulating having a temperature and pressure selected to provide therapy to a subject in need thereof. The cuffs may be applied to the upper arms and upper thighs of a subject in need of improved vitality.