Invention Grant
- Patent Title: Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
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Application No.: US14784489Application Date: 2014-04-16
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Publication No.: US09932327B2Publication Date: 2018-04-03
- Inventor: Ram A. Vishwakarma , Sandip B. Bharate , Shashi Bhushan , Dilip M. Mondhe , Shreyans K. Jain , Samdarshi Meena , Santosh K. Guru , Anup S. Pathania , Suresh Kumar , Akanksha Behl , Mubashir J. Mintoo , Sonali S. Bharate , Prashant Joshi
- Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
- Applicant Address: IN New Delhi
- Assignee: The Council of Scientific & Industrial Research
- Current Assignee: The Council of Scientific & Industrial Research
- Current Assignee Address: IN New Delhi
- Agency: Locke Lord LLP
- Agent Nicholas J. DiCeglie, Jr.
- Priority: IN1142/DEL/2013 20130417
- International Application: PCT/IN2014/000239 WO 20140416
- International Announcement: WO2014/170914 WO 20141023
- Main IPC: C07D405/04
- IPC: C07D405/04 ; A61K31/453 ; C07D405/14
Abstract:
The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.
Public/Granted literature
- US20160052915A1 ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF Public/Granted day:2016-02-25
Information query
