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公开(公告)号：US12226462B2
公开(公告)日：2025-02-18
申请号：US17425619
申请日：2020-01-23
Inventor： Navneet Kaur , Prakash Kumar , Girish Sahni
Abstract: The present invention discloses modified forms of plasmin with advantageous properties. As compared to their natural unmodified form, these variants exhibit significantly modulated kinetics in terms of delayed inhibition characteristics in the presence of specific inhibitors, such as α2-antiplasmin (α2-AP). These include PEG-conjugated thiol derivatives of truncated plasmin with potential clinical applications in various regimens of thrombolytic therapies.
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公开(公告)号：US20250042888A1
公开(公告)日：2025-02-06
申请号：US18710553
申请日：2022-11-24
Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN.
Inventor： Syed GULAM DASTAGER , Madhukar SHYAM SAID , Abujanaid KHAN , Amol ARVIND KULKARNI
IPC: C07D413/06
Abstract: The present disclosure relates to a new, simple, two step synthesis of Indolmycin and its derivatives of formula (I), in 4-5 hours. Formula (I) wherein said process comprising the step of: 10 (a) reacting indole derivative with methyl magnesium bromide in a suitable solvent at a temperature in the range of 0-30° C. followed by adding ethyl epoxy butanone in a suitable solvent at −20° C. for a period of 1-2 hrs and maintaining the obtained reaction mixture for 1 hr at −20° C. to obtain a compound; and (b) passing the compound obtained at step a), base and N-methylated quinidine 15 through solid-solid continuous flow reactor for 1 minute to obtain the compound of formula (I).
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公开(公告)号：US12215197B2
公开(公告)日：2025-02-04
申请号：US17600955
申请日：2020-04-02
IPC: C08G73/18 , C07C17/02 , C07C51/09 , C07C67/347 , C07D235/16
Abstract: The present invention relates to a crystalline, two dimensional polymer of Formula I and a process for the preparation thereof.
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公开(公告)号：US20240313230A1
公开(公告)日：2024-09-19
申请号：US18262225
申请日：2022-01-20
Inventor： Manjusha Vilas SHELKE , Apurva Algesh PATRIKE , Indrapal KARBHAL
IPC: H01M4/66 , B82Y40/00 , H01M4/02 , H01M4/04 , H01M4/38 , H01M4/58 , H01M4/78 , H01M4/80 , H01M10/0525 , H01M10/0567 , H01M10/0568 , H01M10/0569
CPC classification number: H01M4/663 , B82Y40/00 , H01M4/0404 , H01M4/382 , H01M4/5825 , H01M4/78 , H01M4/80 , H01M10/0525 , H01M10/0567 , H01M10/0568 , H01M10/0569 , H01M2004/027 , H01M2004/028 , H01M2300/004 , H01M2300/0051
Abstract: The present invention discloses a 3D rigid mesoporous honeycomb boron carbon nitride (HBCN) nanomaterial as a host for plating/depositing metal. Said nanomaterial plated/deposited with metal is used as metal anode in alkali metal ion battery.
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公开(公告)号：US20240238511A1
公开(公告)日：2024-07-18
申请号：US18560059
申请日：2022-03-04
Inventor： Arindam CHATTERJEE , Sanjeev VERMA , Sourabh DUTTA , Dinesh PANKAJ , Gurinderjit SINGH , Sarbjeet SINGH
CPC classification number: A61M5/1422 , A61M5/1458 , A61M5/16859 , A61M5/16881 , A61M2005/1401 , A61M2005/14208 , A61M2005/16868 , A61M2202/0007 , A61M2202/0014 , A61M2202/0413 , A61M2205/106 , A61M2205/128 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3331 , A61M2205/502 , A61M2210/1466 , A61M2240/00
Abstract: A DVET unit is disclosed that comprises a first syringe and a second syringe having a first plunger and a second plunger, adapted to execute a backward stroke and a forward stroke in the respective syringe. The DVET unit also includes a first valve and a second valve. Further, the first valve is closed and the second valve is opened to draw blood from the source and the specimen into the first syringe and the second syringe. Moreover, the first valve is opened and the second valve is closed to pump the blood, drawn during the backward stroke, from the first syringe and the second syringe into the specimen and the waste bin.
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Patent Agency Ranking
公开(公告)号：US12036214B2
公开(公告)日：2024-07-16
申请号：US17253193
申请日：2019-06-14
Inventor： Sonali Sandip Bharate , Vikas Kumar , Mubashir Javed Mintoo , Dilip Manikrao Mondhe , Sandip Bibishan Bharate , Ram Vishwakarma
IPC: A61K31/453 , A61K9/10 , A61K9/20 , A61K47/10 , A61K47/32 , A61K47/38 , A61K47/40 , A61P35/00 , C07D405/04
CPC classification number: A61K31/453 , A61K9/10 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K47/10 , A61K47/32 , A61K47/38 , A61K47/40 , A61P35/00
Abstract: The present invention is related to the novel solid dispersion formulations of an anticancer compound of formula A and a process for preparing the same wherein the anticancer compound is formulated with hydrophilic polymer. The said formulation showed enhanced dissolution of the anticancer compound and improved in-vivo anticancer activity. The said formulations are useful for the treatment of various types of cancer.
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7.发明公开公开(公告)号：US20240209300A1
公开(公告)日：2024-06-27
申请号：US18166862
申请日：2023-02-09
Inventor： Syed Gulam DASTAGER , Vasudev Sahebrao WAGH
CPC classification number: C12M23/02 , C12N1/20 , C12N2500/34
Abstract: The present invention relates to a process for the production of levan essentially free of contaminating polysaccharides using a bioreactor. More particularly, the present invention relates to a process for the increased production of levan using a strain of marine Bacillus sp. SGD-03. The present invention further relates to the process for efficient production of levan by optimizing media parameters at a microlitre level.
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公开(公告)号：US20240122912A1
公开(公告)日：2024-04-18
申请号：US18553657
申请日：2022-03-29
Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH , JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH
Inventor： Madhan Mohan Chandra Sekhar JAGGARAPU , Eswaramoorthy MUTHUSAMY , Tapas Kamar KUNDU , Rajkumar BANERJEE
IPC: A61K31/4515 , A61K47/68 , A61K47/69 , A61P35/00
CPC classification number: A61K31/4515 , A61K47/6865 , A61K47/6929 , A61P35/00
Abstract: The present invention describes the development of a novel, tumor epithelial cell and tumor-associated macrophage (TAM)-targeting, blood brain barrier (BBB) crossing glucose-based nanospheres (CSP). More specifically, the present invention discloses a nanoformulation and/or a composition having anticancer activity comprising of carbon nanosphere (CSP) and a sigma receptor targeting ligand (H8) in the ratio of 1:0.08 to 1:0.2, a complex prepared thereof, a process for preparation thereof and a kit for delivery of the drug molecule or the formulation or the composition to tumor site.
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公开(公告)号：US20240088665A1
公开(公告)日：2024-03-14
申请号：US18465535
申请日：2023-09-12
Inventor： SANTU KUMAR GIRI , PRATIM BHATTACHARYYA , SIDDHESWAR SEN , NARESH CHANDRA MURMU , SOURAV SADHUKHAN
CPC classification number: H02J3/322 , B60L50/60 , B60L55/00 , H02J3/001 , H02J3/38 , H02M3/33584 , B60L2210/10
Abstract: The present disclosure provides a switched reconfigurable multi-converter multi-source energy storage system configuration for electrified vehicles comprising of multiple dc/dc power converters, multiple energy sources, a mode selector switching module further comprising a plurality of controllable switches and a controller. A method of switching to reconfigure the multi-converter multi-source energy storage system during the dynamic events of variable power demand or regeneration in an electrified vehicle is disclosed. Furthermore, a power flow control scheme for executing the dynamic switching methods of reconfiguration to maneuver the flow of power within the system during different scenarios of forward power delivery or reverse power accumulation is disclosed. The controllable switches are methodically activated or deactivated to couple or decouple the energy sources to or from the input side of the dc/dc power converters by means of necessary activation or deactivation signals from the controller. Nevertheless, a fault tolerant control scheme is disclosed to ensure fail-safe operation of the switched reconfigurable system during the occurrence of fault in any of the dc/dc power converters.
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公开(公告)号：US20240083937A1
公开(公告)日：2024-03-14
申请号：US17961220
申请日：2022-10-06
Inventor： Mahendra Ashok Wagh , Gangadhar Jessy Sanjayan
Abstract: Triple G-C-T base coded nucleobase amino acids according to Formula (I):
wherein R is —H or -Boc, are provided as building blocks for peptide sequences. The compound of formula (I) includes three recognition sites, DDA (G mimic), DAA (C mimic) and ADA (T mimic) that can simultaneously interact with two sets of nucleobases (C-A or G-A), at any given time. A one-step synthetic process for the triple G-C-T base coded nucleobase amino acids is provided.
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