Systems and methods are provided for adaptive configuration and control of digital-to-analog converters (DACs). Performance of a plurality of conversion elements in a digital-to-analog converter (DAC) may be assessed based on particular input conditions associated with a digital input to the DAC, and the DAC may be configured based on the assessing of performance. Each conversion element of the plurality of conversion elements handles a particular bit in the digital input. The configuring may comprise selecting a subset of the plurality of conversion elements, and setting only the subset of the plurality of conversion elements to apply a particular type of operations. The particular type of operations pertains to applying digital-to-analog conversions via the DAC, and the particular type of operations relates to or affects performance. The particular input conditions may comprise signal backoff.