Invention Application
WO2013103614A1 CRLF-2 BINDING PEPTIDES, PROTOCELLS AND VIRAL-LIKE PARTICLES USEFUL IN THE TREATMENT OF CANCER, INCLUDING ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
审中-公开
用于治疗癌症的CRLF-2结合肽，细胞和病毒颗粒，包括急性LYMPHOBLOSTIC LEUKEMIA（ALL）
- Patent Title: CRLF-2 BINDING PEPTIDES, PROTOCELLS AND VIRAL-LIKE PARTICLES USEFUL IN THE TREATMENT OF CANCER, INCLUDING ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
- Patent Title (中): 用于治疗癌症的CRLF-2结合肽，细胞和病毒颗粒，包括急性LYMPHOBLOSTIC LEUKEMIA（ALL）
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Application No.: PCT/US2012/072297Application Date: 2012-12-31
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Publication No.: WO2013103614A1Publication Date: 2013-07-11
- Inventor: BRINKER, C., Jeffrey , PEABODY, David, S. , WHARTON, Walker , CHACKERIAN, Bryce , ASHLEY, Carlee, Erin , WILLMAN, Cheryl, L. , CARNES, Eric, C. , EPLER, Katherine , CASTILLO, Robert, Eric
- Applicant: STC.UNM , SANDIA CORPORATION
- Applicant Address: 801 University Blvd. Se, Ste. 101 Albuquerque, NM 87106 US
- Assignee: STC.UNM,SANDIA CORPORATION
- Current Assignee: STC.UNM,SANDIA CORPORATION
- Current Assignee Address: 801 University Blvd. Se, Ste. 101 Albuquerque, NM 87106 US
- Agency: COLEMAN, Henry, D.
- Priority: US61/581,915 20111230
- Main IPC: C07K7/06
- IPC: C07K7/06 ; C12N11/02 ; A61K47/48 ; C12N15/63 ; A61P35/00
Abstract:
The present invention relates to the use of which are attached or anchored phospholipid biolayers further modified by CRLF-2 and CD 19 binding peptides which may be used for delivering pharmaceutical cargos, to cells expressing CRLF-2 and CD 19, thereby treating cancer, in particular, acute lymphoblastic leukemia (ALL), including (B-precursor acute lymphoblastic leukemia (B-ALL). Novel CRLF-2 binding peptides and CLRF-2 and CD19-binding viral-like particles (VLPs) useful in the treatment of cancer, including ALL are also provided.
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