公开(公告)号：WO2020185464A1

公开(公告)日：2020-09-17

申请号：PCT/US2020/020982

申请日：2020-03-04

Applicant: STC.UNM ,  DURVASULA, Ravi ,  BRADFUTE, Steven ,  KUNAMNENI, Adinarayana

Inventor： DURVASULA, Ravi ,  BRADFUTE, Steven ,  KUNAMNENI, Adinarayana

IPC: A61K39/42 ,  C07K16/10 ,  G01N33/569 ,  A61P31/14

Abstract: An antibody that binds to a filovirus glycoprotein generally includes include a complementarity determining region (CDR) of any one of SEQ ID NO:27-36 or a combination of such CDRs. The antibody may be used in to detect filovirus in a biological sample obtained from a subject. The antibody also may be formulated into a pharmaceutical composition for administering to a subject having, or at risk of having, a filovirus infection.

公开(公告)号：WO2020092609A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/058915

申请日：2019-10-30

Applicant: STC.UNM ,  GUO, Jimin ,  BRINKER, C., Jeffrey ,  ZHU, Wei

Inventor： GUO, Jimin ,  BRINKER, C., Jeffrey ,  ZHU, Wei

IPC: A01N1/02 ,  C12N5/078 ,  B01J20/22 ,  B01J20/28 ,  B82Y5/00

Abstract: Zr-based MOF NPs for cryopreservation of red blood cells.

公开(公告)号：WO2020018482A1

公开(公告)日：2020-01-23

申请号：PCT/US2019/041919

申请日：2019-07-16

Applicant: STC.UNM ,  MA, Thomas Y.

Inventor： MA, Thomas Y.

IPC: A23L33/135 ,  A61K35/745 ,  A61K35/747 ,  A61P1/00 ,  A61P1/16

Abstract: This disclosure describes compositions and methods involving amounts of probiotic bacteria effective to decrease intestinal permeability or intestinal epithelial tight junction permeability in a subject having or at risk of having defective intestinal barrier, increased intestinal permeability and/or intestinal epithelial tight junction permeability compared to a normal subject. The probiotic bacteria can include a Lactobacillus spp. and/or a Bifidobacterium spp.

公开(公告)号：WO2019144087A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/014450

申请日：2019-01-22

Applicant: STC.UNM

Inventor： GARZON, Fernando ,  BALAGOPAL, Shekar

IPC: C25B1/00 ,  C25B9/00 ,  C25B9/08 ,  C01C1/04

Abstract: An electrolytic cell and method for synthesizing ammonia by utilizing a lithium selective membrane in the electrolytic cell and providing at least one lithium halogen salt as an electrolyte in the electrochemical process of producing ammonia. The reaction utilizes a hydrogen halide or hydrogen sulfide as a hydrogen oxidant in the process, and allows the regeneration of lithium halide salts that can be recycled back into the cell reaction.

公开(公告)号：WO2019118881A1

公开(公告)日：2019-06-20

申请号：PCT/US2018/065761

申请日：2018-12-14

Applicant: STC.UNM ,  SOLIMAN, Eslam Mohamed

Inventor： SOLIMAN, Eslam Mohamed ,  TAHA, Mahmoud Reda

IPC: B32B5/08 ,  B32B27/02

CPC classification number: B32B5/08 ,  B32B27/02

Abstract: A 3D printed fiber reinforced polymer composite having a nonlinear stress-strain profile created by a central layer and a plurality of recruited successive layers.

公开(公告)号：WO2019099763A1

公开(公告)日：2019-05-23

申请号：PCT/US2018/061420

申请日：2018-11-16

Applicant: STC.UNM ,  ENKE, Christie

Inventor： ENKE, Christie

IPC: H01J49/40

Abstract: A detector system for targeted analysis and/or sample collection by distance-of-flight mass spectrometry (tDOF-MS).

公开(公告)号：WO2019018443A1

公开(公告)日：2019-01-24

申请号：PCT/US2018/042559

申请日：2018-07-17

Applicant: STC.UNM

Inventor： SALAS, Christina ,  ABOUBAKR, Sherif Hassan Abdelkader ,  NERY, Steven ,  BUKSA, Christopher ,  HAMILTON, Alexander

IPC: A61L27/12 ,  A61L27/10 ,  A61L27/52 ,  A61F2/08 ,  A61F2/28 ,  B33Y10/00 ,  B33Y30/00

Abstract: A device for regenerating musculoskeletal tissue having a scaffold comprised of fiber layers adapted to provide mechanical integrity to the scaffold in the form of increased tensile and compressive resistance and one or more other layers adapted to provide mechanical integrity and to provide a suitable biochemical environment.

公开(公告)号：WO2018053421A1

公开(公告)日：2018-03-22

申请号：PCT/US2017/052050

申请日：2017-09-18

Applicant: STC.UNM ,  UNIVERSITY OF COLORADO, COLORADO SPRINGS ,  NEUMANN, Aaron K. ,  PINCHUK, Anatoliy O. ,  JIANG, Ke

Inventor： NEUMANN, Aaron K. ,  PINCHUK, Anatoliy O. ,  JIANG, Ke

IPC: C12Q1/04 ,  C12N1/00 ,  C12N1/14 ,  C12N1/20 ,  G01N21/65

Abstract: Methods and apparatus for rapid, culture and/or label free pathogen detection. The methods utilize optical spectroscopy techniques to identify and/or characterize pathogens in a sample via the detection of unique properties and/or analytes that are specific to particular pathogens.

Abstract translation: 快速，培养和/或标记自由病原体检测的方法和设备。 该方法利用光谱学技术通过检测对特定病原体特异的独特性质和/或分析物来鉴定和/或表征样品中的病原体。

公开(公告)号：WO2018053411A1

公开(公告)日：2018-03-22

申请号：PCT/US2017/052032

申请日：2017-09-18

Applicant: STC.UNM ,  NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC

Inventor： NEUMANN, Aaron, K. ,  GRAUS, Matthew, S. ,  TIMLIN, Jerilyn, A.

IPC: C12Q1/04 ,  C12N1/00 ,  C12N1/14 ,  G01N21/64

Abstract: Methods and apparatus for rapid, culture free pathogen detection. The methods utilize optical spectroscopy techniques to identify and/or characterize pathogens in a sample via the detection of unique properties and/or analytes that are specific to particular pathogens.

Abstract translation: 用于快速无培养病原体检测的方法和设备。 该方法利用光谱学技术通过检测对特定病原体特异的独特性质和/或分析物来鉴定和/或表征样品中的病原体。

公开(公告)号：WO2018052981A1

公开(公告)日：2018-03-22

申请号：PCT/US2017/051331

申请日：2017-09-13

Applicant: STC.UNM ,  HAMIDOVIC, Ajna

Inventor： HAMIDOVIC, Ajna

IPC: A61K38/28 ,  A61P25/34

CPC classification number: A61K38/28 ,  A61K9/0043 ,  A61K9/12 ,  A61P25/34

Abstract: A method of treating a subject for acute nicotine withdrawal generally includes intranasally administering to the subject a dose of insulin effective to ameliorate at least one symptom or clinical sign of nicotine withdrawal. In some embodiments, the dose of insulin can be at least 45 IU and no more than 75 IU. In one particular embodiment, the dose can be 60 IU. In some embodiments, the dose can be an amount effective to restore at least a portion of a nicotine-withdrawal-associated decrease in saliva Cortisol level following a stress stimulus. In some embodiments, the dose can be an amount effective to decrease an urge to smoke a cigarette during acute withdrawal from nicotine.

Abstract translation: 治疗急性尼古丁戒断的受试者的方法通常包括向受试者鼻内施用有效改善至少一种尼古丁戒断症状或临床征兆的剂量的胰岛素。 在一些实施方案中，胰岛素的剂量可以是至少45IU且不超过75IU。 在一个特定实施例中，剂量可以是60IU。 在一些实施方案中，剂量可以是有效恢复应激刺激后唾液皮质醇水平的尼古丁戒除相关降低的至少一部分的量。 在一些实施方案中，剂量可以是有效减少在急性戒断尼古丁期间抽吸香烟的冲动的量。