公开(公告)号：WO2023021496A2

公开(公告)日：2023-02-23

申请号：PCT/IB2022/062058

申请日：2022-12-12

Applicant: KING KHALID UNIVERSITY ,  M.S. RAMAIAH INSTITUTE OF TECHNOLOGY

Inventor： AL-SEHEMI, Abdullah G. ,  FARID, Arshad ,  PANNIPARA, Mehboobali ,  SAH, Ranjit ,  CHIGURUPATI, Sridevi ,  CHINNAM, Sampath ,  AHMAD, Iqrar ,  PATEL, Harun ,  ALSHAHRANI, Mohammad Y ,  SINGH, Preet Amol ,  BAJWA, Neha

IPC: C07D239/545 ,  C07C275/00 ,  C07C201/00

Abstract: The current invention offers a one-pot, two-component green synthetic protocol as potent antioxidant drug candidates of novel synthesized urea analogues. All the compounds were evaluated for in vitro antioxidant studies by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) methods. In both DPPH and in H2O2 methods, compounds 3a, and 3c exhibited noteworthy antioxidant activity compared with the standard drug ascorbic acid at various concentrations of 25, 50, 75, and 100 µg/mL. The protocol has various advantages such as green synthetic route, short reaction times, excellent yields, simple work-up procedure, no column chromatography, and potential antioxidant agents.