公开(公告)号：US11912760B2

公开(公告)日：2024-02-27

申请号：US17350763

申请日：2021-06-17

Applicant: PHAROSGEN CO., LTD

Inventor： Youngro Byun ,  Ha Kyeong Lee ,  So Young Choi ,  So Ra Park ,  Se Ra Lee ,  Seung Il Baek

IPC: A61K39/395 ,  A61K39/00 ,  G01N33/53 ,  A61K49/00 ,  C07K16/46 ,  C07K16/00 ,  C07K16/18 ,  G01N33/68 ,  A61P35/00

CPC classification number: C07K16/18 ,  A61P35/00 ,  G01N33/68 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Described herein are doppel-targeting molecules (e.g., antibodies) useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

公开(公告)号：US20220267422A1

公开(公告)日：2022-08-25

申请号：US17350763

申请日：2021-06-17

Applicant: PHAROSGEN CO., LTD

Inventor： Youngro BYUN ,  Ha Kyeong LEE ,  So Young CHOI ,  So Ra PARK ,  Se Ra LEE ,  Seung Il BAEK

IPC: C07K16/18 ,  G01N33/68 ,  A61P35/00

Abstract: Described herein are doppel-targeting molecules (e.g., antibodies) useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

公开(公告)号：WO2018164441A1

公开(公告)日：2018-09-13

申请号：PCT/KR2018/002625

申请日：2018-03-06

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  PHAROSGEN ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： BYUN, Young Ro ,  KIM, In San ,  TASLIM, Ahmed Al-Hilal ,  KIM, Sang Yoon ,  JANG, Ye Ji

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2872 ,  A61K2039/505 ,  C07K2317/73 ,  C07K2317/76

Abstract: There is provided an antibody that binds to doppel or a doppel-binding fragment thereof, comprising a heavy chain variable region and a light chain variable region. The doppel-targeting molecules are capable of inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject.

公开(公告)号：US20180185498A1

公开(公告)日：2018-07-05

申请号：US15690157

申请日：2017-08-29

Applicant: Pharosgen Co., Ltd.

Inventor： Sang-Yoon KIM ,  Youngro Byun ,  Seung Woo Chung

IPC: A61K47/55

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

公开(公告)号：US09775914B2

公开(公告)日：2017-10-03

申请号：US14796219

申请日：2015-07-10

Applicant: PHAROSGEN CO., LTD.

Inventor： Sang-Yoon Kim ,  Youngro Byun ,  Seung Woo Chung

IPC: A61K47/48 ,  A61K31/65 ,  A61K31/337 ,  A61K45/06 ,  A61N1/40 ,  A61K38/14 ,  A61B18/02 ,  A61N7/00 ,  A61N5/067 ,  A61N5/06 ,  A61N7/02

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

公开(公告)号：WO2017095136A9

公开(公告)日：2017-06-08

申请号：PCT/KR2016/013956

申请日：2016-11-30

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  PHAROSGEN ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： BYUN, Young Ro ,  KIM, In San ,  TASLIM, Ahmed Al-Hilal ,  KIM, Sang Yoon ,  JANG, Ye Ji

IPC: A61K31/727 ,  A61K39/395 ,  A61K48/00 ,  C07K14/705 ,  C07H3/06 ,  C07K16/28 ,  C07K16/30 ,  C12N15/113

Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

公开(公告)号：WO2016080626A3

公开(公告)日：2016-08-25

申请号：PCT/KR2015007165

申请日：2015-07-10

Applicant: PHAROSGEN

Inventor： KIM SANG YOON ,  BYUN YOUNG RO ,  CHUNG SEUNG WOO

IPC: C07D309/10 ,  A61K31/4015 ,  A61K31/7042 ,  A61K38/08 ,  A61K47/48 ,  A61P35/00

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/48338 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

Abstract translation: 描述了在通过胱天蛋白酶激活时释放化学治疗剂的前药缀合物，以及使用这种前药缀合物诱导凋亡，扩增凋亡和治疗癌症的方法。

公开(公告)号：WO2017095136A1

公开(公告)日：2017-06-08

申请号：PCT/KR2016/013956

申请日：2016-11-30

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  PHAROSGEN ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： BYUN, Young Ro ,  KIM, In San ,  TASLIM, Ahmed Al-Hilal ,  KIM, Sang Yoon ,  JANG, Ye Ji

IPC: A61K31/727 ,  A61K39/395 ,  A61K48/00 ,  C07K14/705 ,  C07H3/06 ,  C07K16/28 ,  C07K16/30 ,  C12N15/113

CPC classification number: C07K16/2872 ,  A61K31/727 ,  A61K47/554 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/14 ,  C07K2317/73 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3515 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/705

Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

Abstract translation: 本文描述了用于抑制病理性血管生成和治疗与病理性血管生成相关的疾病和病症的多巴靶向分子，所述疾病和病症例如肿瘤，癌症，动脉粥样硬化，肺结核，哮喘，肺动脉高血压（PAH），肿瘤 和肿瘤相关的病症，并用于检测受试者中的doppel表达。 还描述了相关的组合物和方法。

公开(公告)号：WO2016080626A2

公开(公告)日：2016-05-26

申请号：PCT/KR2015/007165

申请日：2015-07-10

Applicant: PHAROSGEN

Inventor： KIM, Sang Yoon ,  BYUN, Young Ro ,  CHUNG, Seung Woo

IPC: C07D309/10 ,  A61K47/48 ,  A61K31/4015 ,  A61K38/08 ,  A61K31/7042 ,  A61P35/00

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

Abstract translation: 描述了通过半胱天冬酶活化释放化学治疗剂的前药缀合物，以及使用此类前药缀合物诱导细胞凋亡，放大细胞凋亡并治疗癌症的方法。

公开(公告)号：US10357572B2

公开(公告)日：2019-07-23

申请号：US15690157

申请日：2017-08-29

Applicant: Pharosgen Co., Ltd.

Inventor： Sang-Yoon Kim ,  Youngro Byun ,  Seung Woo Chung

IPC: A61N1/40 ,  A61N5/06 ,  A61N7/00 ,  A61N7/02 ,  A61B18/02 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  A61K47/65 ,  A61N5/067 ,  A61K31/337

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.