公开(公告)号：US20220267422A1

公开(公告)日：2022-08-25

申请号：US17350763

申请日：2021-06-17

Applicant: PHAROSGEN CO., LTD

Inventor： Youngro BYUN ,  Ha Kyeong LEE ,  So Young CHOI ,  So Ra PARK ,  Se Ra LEE ,  Seung Il BAEK

IPC: C07K16/18 ,  G01N33/68 ,  A61P35/00

Abstract: Described herein are doppel-targeting molecules (e.g., antibodies) useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.