公开(公告)号：EP0487657A1

公开(公告)日：1992-06-03

申请号：EP91907677.0

申请日：1991-04-04

Applicant: GLAXO INC. ,  JOHNSON, M. Ross ,  PEEL, Michael R. ,  STERNBACH, Daniel D.

Inventor： JOHNSON, M., Ross ,  PEEL, Michael, R. ,  STERNBACH, Daniel, D.

IPC: C07D473 ,  C07F7

CPC classification number: C07F7/0818 ,  C07D473/00

Abstract: Nouveau procédé de préparation de certains dérivés optiquement actifs de cyclopentène, et nouveaux intermédiaires utilisés par ce procédé. On décrit en particulier la synthèse de l'isomère 1'R-cis de carbovir, (1'R-cis)-2-amino-1,9-dihydro-9[4-(hydroxyméthyle)-Z-cyclopentène-1-yle]-6H-purine-6-one.

公开(公告)号：EP0487657A4

公开(公告)日：1993-06-09

申请号：EP91907677

申请日：1991-04-04

Applicant: GLAXO INC. ,  JOHNSON, M. ROSS ,  PEEL, MICHAEL R. ,  STERNBACH, DANIEL D.

Inventor： JOHNSON, M., ROSS ,  PEEL, MICHAEL, R. ,  STERNBACH, DANIEL, D.

IPC: C07D473/00 ,  C07F7/08 ,  C07D473/18 ,  C07D473/40 ,  C07F7/10

CPC classification number: C07F7/0818 ,  C07D473/00

Abstract: This invention relates to a new process for preparing certain optically active cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1'R-cis isomer of carbovir, (1'R-cis)-2-amino-1,9 dihydro-9[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent.

公开(公告)号：WO1991015489A1

公开(公告)日：1991-10-17

申请号：PCT/US1991002345

申请日：1991-04-04

Applicant: GLAXO INC. ,  JOHNSON, M., Ross ,  PEEL, Michael, R. ,  STERNBACH, Daniel, D.

Inventor： GLAXO INC.

IPC: C07D473/18

CPC classification number: C07D473/00 ,  C07F7/081

Abstract: This invention relates to a new process for preparing certain optically active cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1'R-cis isomer of carbovir, (1'R-cis)-2-amino-1,9-dihydro-9[4-(hydroxymethyl)-2-cyclopenten-1-yl]- 6H-purin-6-one, an antiviral agent.