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公开(公告)号：KR1020140061834A
公开(公告)日：2014-05-22
申请号：KR1020120128941
申请日：2012-11-14
Applicant: 가톨릭관동대학교산학협력단
IPC: A61K31/4196 , A61K31/40 , A61P9/12
CPC classification number: A61K31/12 , A61K2121/00
Abstract: The present invention relates to an improved method for preparing derivatives of farnesyl acetone as an antihypertensive agent and the derivatives composed by the same. More specifically, the present invention relates to a new synthesis method of 6,10,14-trimethyl-deca-penta-5,10-diene-2,12-dione and derivatives synthesized by the same or relates to a synthesis method of of 6,10,14-trimethyl-deca-penta-5,10-diene-2,12-dione and derivatives synthesized by the same.
Abstract translation: 本发明涉及一种制备法呢基丙酮衍生物作为抗高血压剂及其衍生物的改进方法。 更具体地说，本发明涉及6,10,14-三甲基 - 十五 - 5,10-二烯-2,12-二酮的新合成方法及其合成方法或其合成方法 6,10,14-三甲基 - 十 - 五 - 5,10-二烯-2,12-二酮及其合成的衍生物。
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公开(公告)号：KR101058530B1
公开(公告)日：2011-08-23
申请号：KR1020090109022
申请日：2009-11-12
Applicant: 가톨릭관동대학교산학협력단
IPC: C07D317/10 , A61K31/40 , A61K31/4196 , A61P9/12
Abstract: 본 발명은 고혈압 치료제인 파네실아세톤 유도체의 제조방법 및 이의 중간체에 관한 것으로, 보다 구체적으로는 신규한 중간체를 사용하여 6,10,14-트리메틸펜타데카-5,10-디엔-2,12-디온을 유기합성하는 방법에 관한 것이다.
6,10,14-트리메틸펜타데카-5,10-디엔-2,12-디온Abstract translation: 本发明涉及一种制造腔室的Ipanema丙酮衍生物的抗高血压剂的方法，并且涉及其中间体，更具体地，6,10,14-三甲基癸五二烯-5,10- -2,12-使用新的中间体 Dione。＆lt;
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公开(公告)号：KR101405531B1
公开(公告)日：2014-06-11
申请号：KR1020120128941
申请日：2012-11-14
Applicant: 가톨릭관동대학교산학협력단
IPC: A61K31/4196 , A61K31/40 , A61P9/12
Abstract: 본 발명은 고혈압 치료제인 파네실아세톤 유도체의 개선된 제조방법 및 이의 방법에 의해 합성된 유도체에 관한 것으로, 보다 구체적으로는 신규한 합성방법에 의해 6,10,14-트리메틸펜타데카-5,10-디엔-2,12-디온의 제조방법 및 이의 제조방법으로 합성된 유도체 및/또는 6,10,14-트리메틸펜타데카-5,10-디엔-2,12-디온 유도체의 제조방법 및 이의 제조방법으로 합성된 유도체에 관한 것이다.
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公开(公告)号：KR1020110052109A
公开(公告)日：2011-05-18
申请号：KR1020090109022
申请日：2009-11-12
Applicant: 가톨릭관동대학교산학협력단
IPC: C07D317/10 , A61K31/40 , A61K31/4196 , A61P9/12
Abstract: PURPOSE: A method for preparing farnesylactone derivatives and an intermediate of the derivative are provided to effectively perform organic synthesis of 6,10,14-trimethylpentadeca-5,10-diene-2,12-dione. CONSTITUTION: A method for preparing farnesylactone compound comprises: a step of reacting a compound of chemical formula 4 with ethylene glycol and p-toluene sulfonic acid to prepare a compound of chemical formula 5; a step of reacting the compound of chemical formula 5 with sodium methoxide to obtain a compound of chemical formula 6; a step of reacting the compound of chemical formula 6 with diisobutyl aluminum hydride to obtain a compound of chemical formula 7; a step of reacting the compound of chemical formula 7 with isobutyl magnesium bromide to obtain a compound of chemical formula 8; a step of reacting the compound of chemical formula 8 with pyridinium chloro chromate to obtain a compound of chemical formula 9; and a step of reacting the compound of chemical formula 9 with pyridium p-toluenesulfonate.
Abstract translation: 目的：提供制备法呢基内酯衍生物和衍生物中间体的方法，以有效地进行6,10,14-三甲基十五碳-5,10-二烯-2,12-二酮的有机合成。 构成：制备法呢基酯化合物的方法包括：使化学式4的化合物与乙二醇和对甲苯磺酸反应制备化学式5的化合物的步骤; 使化学式5的化合物与甲醇钠反应以获得化学式6的化合物的步骤; 使化学式6的化合物与二异丁基氢化铝反应得到化学式7的化合物的步骤; 使化学式7的化合物与异丁基溴化镁反应以获得化学式8的化合物的步骤; 使化学式8的化合物与氯铬酸吡啶鎓反应以获得化学式9的化合物的步骤; 和使化学式9化合物与对甲苯磺酸吡啶鎓反应的步骤。
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